Department of Medicinal Chemistry and Toxicology
Scientific work
Scientific supervisor – Head of the Department, MD, Prof. Iryna Nizhenkovska
Responsible person – PhD in Pharmacology, Associate Professor Violetta Narokha
Main fields of scientific work are:
- synthesis and pharmacological evaluation of the biological activity of new compounds in silico and in vivo
- biochemistry and pathobiochemistry of molecular mechanisms of biomembranes damage and therapeutico-prophylactic use of bioantioxidants
- educational and methodological support, reformation of higher pharmaceutical education, introduction of modern educational technologies with consideration of specifics of organic, biological, pharmaceutical and toxicological chemistry for students of the Faculty of Pharmacy
Scientific themes:
2024-2026
- “Study of the effect of coordination compounds of germanium and derivatives of heterocycles on the processes of cell death” Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – PhD Violetta Narokha
- “Theoretical and methodological principles of professional training of future Masters of Pharmacy using the latest information technologies in the conditions of classroom-distance form of education” Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – Iryna But
2022-2025
- “Development and improvement of methods for laboratory analysis of medical supplies (MS) and biologically active supplements (BAS) ”. Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – PharmD Olena Welchinska.
2021-2023
- “Search and study of pharmacological properties of coordination compounds of germanium and derivatives of heterocycles” Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – PhD Violetta Narokha
- “Theoretical and methodological principles of the organization of educational activities in the study of chemical disciplines by future masters of pharmacy in a mixed classroom-distance form of education” Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – Iryna But
2018-2020
- «Search and study of mechanisms of action of new potential cardioprotective and antihypertensive compounds». Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – PhD Violetta Narokha
- «Experimental rationalization for the creation of a new drug with antimicrobial and anti-inflammatory activity» Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – Ludmila Onyshchuk
DEFENDED THESIS
Doctor of Science (D)
2018
Tetyana Reva. Theoretical and methodological bases of realization of the competence approach in training of chemical disciplines of future pharmacists. Scientific consulting – MD, PhD Iryna Nizhenkovska.
Candidate of Sciences (PhD)
2025
Manchenko Oksana Methodology of teaching drug standardisation to future masters of pharmacy using digital technologies. Supervisor – Prof. Iryna Nizhenkovska.
2024
But Iryna Methods of teaching pharmaceutical chemistry to future masters of pharmacy in the setting of classroom and distance learning. Supervisor – Prof. Iryna Nizhenkovska.
2021
Liudmуla Onyshchuk. Experimental justification for the creation of a new drug with antimicrobial and anti-inflammatory activity. Supervisor – Prof. Iryna Nizhenkovska.
2020
Oksana Golovchenko. Methods of organizing independent work of future masters of pharmacy in organic chemistry by means of distance learning. Supervisor – Prof. Iryna Nizhenkovska.
2019
Kateryna Matskevych. Experimental study of phosphorylated oxazole derivatives as potential antihypertensive agents. Supervisor – Prof. Iryna Nizhenkovska.
2018
Violetta Narokha. Experimental study of the pharmacodynamics of germanium coordination compounds in case of anthracycline intoxication. Supervisor – Prof. Iryna Nizhenkovska.
2017
Vitalii Pidchenko. Experimental justification of immunomodulating ctivity and safety of fungal biomass powder of fungus GANODERMA LUCIDUM (CURT.:FR.)P.KARST». Supervisor – Prof. Iryna Nizhenkovska.
Publications in Scopus та Web of Science
2025
Bahrieieva O. S., Kachaeva M. V., Kobzar O. L., Shulga Y. V., Golovchenko O. V., Golovchenko O. I., Nizhenkovska I. V., Mykhailenko O. V., Pilyo S. G., Zhirnov V. V., Brovarets V. S. (2025) Synthesis, Anticancer Screening, and Virtual Analysis of 5-S-Substituted Derivatives of 1,3-Oxazol-4-ylphosphonates and 1,3-Oxazole-4-carbonitriles Synopen, 2025, 9(4), pp. 268–281 DOI: 10.1055/a-2741-9575 Scopus Q2
Nizhenkovska I., Welchinska O., Gorchakova N. Narokha, V (2025). Modelling/prediction of physico-chemical parameters, biological activity and pharmacokinetics of the derivative of DL-tryptophan in silico. Phytotherapy Journal, 3, 13–21, doi: https://doi.org/10.32782/2522-9680-2025-3-13 Scopus Q4
Nizhenkovska, I.V., Kuznetsova, O.V., Narokha, V.P., Labudzynskyi, D.O. Biomarkers of apoptosis and endoplasmic reticulum stress in cardiomyocytes of rats under chronic ethanol consumption and germanium-nicotinic acid complex administration Ukrainian Biochemical Journal, 2025, 97(1), pp. 51–61
doi: https://doi.org/10.15407/ubj97.01.051 Scopus Q4
О.А. Syrotchuk, O.O. Glushachenko, N. A. Khromova, R.O. Markin, I.R. Didukh, I.V. Nizhenkovska (2025) Determination of quality markers in supercritical CO₂ extracts of millet Phytotherapy Journal, 2, 218-227. doi https//doi.org/10.32782/2522-9680-2025-2-218 Scopus Q4
Diana Hodyna, Oksana Bahrieieva, Yurii Shulga, Vasyl Kovalishyn, Oleksandr Golovchenko, Oksana Golovchenko, Maryna Kachaeva, Stepan Pilyo, Olena Trokhimenko, Larysa Metelytsia, Volodymyr Brovarets (2025) In Silico and In Vitro Studies of 1,3-Oxazol-4-yl Phosphonium Salts as Dual-Functional Antibacterial and Anticancer Agents Chemistry Select: Volue 10, Issue 20, May 26, 2025 https://doi.org/10.1002/slct.202500282 Scopus Q3
Bobrytska, V. I., Reva, Т. D., Krasylnykova, H. V., Protska, S. M., Krasylnykov, S. R., But I. O. (2025). Enhancing Higher Education: Integrating Micro-Credentials and Digital Badges into University Curricula in Ukraine. Ricerche di Pedagogia e Didattica. Journal of Theories and Research in Education. Vol. 20, No. 1, pp. 63-79, 2025. Scopus Q4
https://www.scimagojr.com/journalsearch.php?q=21100921057&tip=sid&clean=0#google_vignette
2024
Iryna Nizhenkovska, Olena Kuznetsova, Violetta Narokha (2024) Effect of vitamin B3/niacin complex with germanium (VI) on the content of fatty acids in the brain, liver and kidneys of alcohol-exposed rats. Current Topics in Pharmacology. Volume 28. 2024. P. 29 – 36 https://www.scopus.com/pages/publications/105007566944?origin=resultslist Scopus Q4
Olena Kuznetsova, Iryna Nizhenkovska, Violetta Narokha (2024) Effect of Distance, mixed and face-to-face Learning on pharmacy students’ Performance in Biochemistry in Ukraine. Journal of Advanced Pharmacy Education and Research. 2024; 14(4), pp. 34–40 DOI: 10.51847/z2hDLmJ2va Scopus Q3
Manchenko, O., Nizhnik, V., Kuryliuk, O., Iukhymenko, N., Budzinska, V. (2024) Some Features of the Chemical Plasticization of Polymers Wihtout Side Groups
Conference Paper Springer Proceedings in Physics, 2024, 253 SPP, рр 65–72
http://dx.doi.org/10.1007/978-3-031-67519-5_6 Scopus Q4
Nizhenkovska, I., Reva, T., Kuznetsova, O. Nizhenkovskyi, O., Chkhalo, O. (2024). A comparison study of artificial intelligence-driven no-code applications for drug discovery and development. ScienceRise: Pharmaceutical Science, 6 (52), 80–89. Scopus Q3
http://doi.org/10.15587/2519-4852.2024.318920
O.A. Syrotchuk, I.V. Nizhenkovska, O.O. Glushachenko, M.A. Bysko, R.O. Markin (2024) Optimization of Conditions for GC-HS Determination of 1,4-Dioxane in Children’s Cosmetic Products, Methods Objects Chem. Anal., 2024, 19(4), p. 187-193 https://doi.org/10.17721/moca.2024.187-193 Scopus Q4
Welchinska, O., Nizhenkovska, I., Meleshko, R. (2024) Modern approaches to the pharmaceutical analysis by HPLC of paclitaxel alkaloid Phytotherapy Journal Open source preview, 2024, 2024(3), pp. 168–171 doi: https://doi.org/10.32782/2522-9680-2024-3-168 Scopus Q4
Nizhenkovska І., Afanasenko О., Nizhenkovskіу A. (2024). Adaptyvne testuvannia v farmatsevtychnii osviti: stratehii ta perevahy [Adaptive testing in pharmaceutical education: strategies and benefits]. Fitoterapiia. Chasopys –Phytotherapy. Journal, 2, 119-124. DOI: https://doi.org/10.32782/2522-9680-2024-2-119 Scopus Q4
V.P. Narokha, I.V. Nizhenkovska, O.V. Kuznetsova. (2024) Analysis of trends in physiologically based pharmacokinetic modelling in silico in translational studies of monoclonal antibodies. Biopolymers and Cell. 2024. Vol. 40. N 3. P 226-226. DOI:
http://dx.doi.org/10.7124/bc.000ACE Scopus Q4
Monika Sobiech, Piotr Luliński, Karol Synoradzki, Tamara J. Bednarchuk, Marta Janczura, Veronika Provorova, Joanna Giebułtowicz. (2024) Implementing magnetic molecularly imprinted solid phase extraction to analytical method for determination of 2-phenethylamine in cocoa powder and chocolate by LC-MS/MS system. Microchemical Journal, Volume 205, 2024, 111155, ISSN 0026-265X. DOI: https://doi.org/10.1016/j.microc.2024.111155. Scopus Q1
2023
Nizhenkovska, I., Kuznetsova, O., Narokha V. Intensity of endoplasmatic reticulum stress, autophagy, and apoptosis in the cerebral cortex of rats with chronic ethanol consumption under the influence of the complex compound of germanium with nicotinic acid ScienceRise: Pharmaceutical Science, No 6(46) 2023, 70-78. DOI: https://doi.org/10.15587/2519-4852.2023.295491 Scopus Q3
Nizhenkovska, K. Matskevych, O. Golovchenko, et al. New Prospective Phosphodiesterase Inhibitors: Phosphorylated Oxazole Derivatives in Treatment of Hypertension. Adv Pharm Bull, 2023, 13 (2). 399-407. DOI: https://doi.org/10.34172/apb.2023.044 Scopus, Q1
Syrotchuk О.А., Musiienko I., Didukh I.R., Nizhenkovska I.V., Glushachenko O.O. Eco-friendly HPLC method for caffeine in dietary supplement determination using ethanol-water mobile phase and PFP-column Journal of Applied Pharmaceutical Sciences Vol. 13(08), pp 151-157, August, 2023. DOI: https://doi.org/10.7324/JAPS.2023.49358 Scopus, Q2
2022
Iryna V. Nizhenkovska, Tatiana D. Reva, Oksana M. Chkhalo, Iryna O. But, Oksana V. Manchenko Best Practices for Teaching Chemistry Disciplines to Graduates Majoring in Pharmacy during the COVID-19 Restrictions: A Systematic Review. International Journal of Educational Methodology, v8 n4 p769-781 2022. DOI: https://doi.org/10.12973/ijem.8.4.769 Scopus, Q3
Stanislav E. Mezhov, Mihail G. Levin, Aleksei A. Gumenyuk, Natalia V. Ostanina, Olena V. Velchinska Counterfeiting dietary supplements by adding undeclared active pharmaceutical ingredients or their analogues to their composition is a new threat to the health of the population and a challenge to the national health care system Wiadomości Lekarskie Medical Advances, Vol. LXXVI, Issue 4, April 2023 p. 877. http://ir.librarynmu.com/handle/123456789/9119 Scopus, Q3
Narokha V.P., Nizhenkovska I.V., Kuznetsova O. V. Potential of germanium-based compounds in coronavirus infection Acta Pharm. 72 (2022) 245-258. DOI: https://doi.org/10.2478/acph-2022-0016 Scopus Q2
Afanasenko, O. V., Nizhenkovska, I. V., Holovchenko, O. I., & Glushachenko, O. O. (2022). Technology-enhanced constructivist learning environment for pharmacy students. Pharmacy Education, 22(1), p. 778–787. DOI: https://doi.org/10.46542/pe.2022.221.778787 Scopus Q3
Korzh, I., Olieinikova, N., Beketova, M., Kubarieva, I., Korobova, Y., Sevriukov, O., & Afanasenko, O. (2022). Comparative analysis of drug consumption for the treatment of epilepsy in Ukraine, Kazakhstan and Belarus. ScienceRise: Pharmaceutical Science, (2(36), 26–36. DOI: https://doi.org/10.15587/2519-4852.2022.255840 Scopus Q3
2021
Nizhenkovska I.V., Onyshchuk L.V., Nizhenkovskyi O. I. Sensitivity of mixed cultures of microorganisms to the new combined drug in the form of pessaries. Curr Top Pharm. 25 (2021) 91-96. http://ir.librarynmu.com/handle/123456789/9769 Scopus Q4
Nizhenkovska IV., Reva Tetiana, Kucherenko Іnna, Stuchynska Natalia, Konovalova Liudmyla та ін. Digital Component of professional competence of Masters of Pharmacy in the framework of Blended learning Arch Pharm Pract 2021;12(1):98-102. DOI: https://doi.org/10.51847/avsEptmZsN Scopus –
2020
Nizhenkovska I.V., Matskevych K.V., Golovchenko O.V., Golovchenko O.I. The effect of OVP-1 on blood pressure and parameters of general hemodynamics in acute arterial hypertension in rabbits. Azerbaijan Pharmaceutical and Pharmacoterapy Journal. No1. 2020. P. 40-45. http://ir.librarynmu.com/handle/123456789/9130 Scopus Q4
Iryna Nizhenkovska, Olena Kuznetsova, Violetta Narokha. Organising distance learning for Master`s in Pharmacy in Ukraine during COVID-19 quarantine – Pharmacy Education. 2020 20(2) 59-60. DOI: https://doi.org/10.46542/pe.2020.202.5960 Scopus Q4
І.М. Пельо, Т.Д. Рева, І.В. Ніженковська, Н.Д. Козак, Л.Д. Коновалова Тенденції професійної підготовки фахівців із фармації в Україні. Medicni perspektivi. 2020; 25(3):4-8. DOI: https://doi.org/10.26641/2307-0404.2020.3.214543 Web of Science
Nizhenkovska I. V., Reva T. D., Chhalo O. M., Golovchenko O.I. Technology-Driven Self-Directed Learning of Graduate Pharmaceutists: Adding Value through Entrepreneurship International Journal of Learning, Teaching and Educational Research. 2020. Vol. 19, No 6, рр.111- 126, June 2020. http://ir.librarynmu.com/handle/123456789/9161 Scopus Q4
2019
Tetiana Reva, Iryna Nizhenkovska, Olena Holik. Didactical aspects of professional training of future masters of pharmacy students / CBU International Conference Proceedings 2019. Vol 7 (2019). – P. 606-610. DOI: https://doi.org/10.12955/cbup.v7.1426 Web of Science
Welchinska Elena. The use of forensic chemistry methods in the determination of counterfeit drugs. In P. Hájek, & O. Vít (Ed.), CBU International Conference Proceedings. 7, pp. 858-863. Prague: CBU Research Institute. http://ir.librarynmu.com/handle/123456789/9407 Web of Science
2018
Nizhenkovska I., Sedko K., Kuznetsova O. Study of influence of 1,3-oxazole-4-yl-phosphonic acid derivative on nitric oxide system indicators in rats with arterial hypertension Ceska a Slovenska Farmacie. 2018. №4 (67), Р. 154-159. http://ir.librarynmu.com/handle/123456789/853 Scopus Q3
Iryna Nizhenkovska, Violetta Narokha, Olena Kuznetsova Effects of nicotinic acid on protein oxidative modification in experimental chronic heart failure. Farmacia, 2018, Vol. 66, 6- Р.959-962.
DOI: http://doi.org/10.31925/FARMACIA.2018.6.5 Scopus Q2
Nizhenkovska I., Sedko K., Golovchenko O.I., Golovchenko O.V. Efficiency of the application of the 1,3-oxazole-4-il-phosphonic acid derivative on the sustained arterial hypertension model in rats. Current Topics in Pharmacology. 2018. 22: 63-68. http://ir.librarynmu.com/handle/123456789/846 Scopus Q4
Nizhenkovska I.V., Zinchenko L.V. Acute toxicity study of a new complex drug with anti-inflammatory activity, Current Topics in Pharmacology. 2017; Vol. 21: 71-74. http://ir.librarynmu.com/handle/123456789/9765 Scopus Q4
Iryna Nizhenkovska, Nadia Gorchakova, Ganna Zaychenko, Violetta Narokha. Uracil as the basis for medication creation. Current Topics in Pharmacology. 2018. 22: 19-26. http://ir.librarynmu.com/handle/123456789/1173 Scopus Q4
Welchinska Elena. Halothane (2-Bromo-1,1,1-trifluoro-2-chloroethane) as example in discipline “Forensic chemistry” for Ukrainian students of pharmacy. Vol 6 (2018): CBU International Conference Proceedings 2018. Prague, Czech Republic. DOI: http://dx.doi.org/10.12955/cbup.v6.1316 Web of Science
