Department of Medicinal Chemistry and Toxicology

Scientific work

Scientific work

Scientific supervisor – Head of the Department, MD, Prof. Iryna Nizhenkovska

irynanizhenkovska@nmu.ua

Responsible person – PhD in Pharmacology, Associate Professor Violetta Narokha

v.narokha@nmu.ua

 

Main fields of scientific work are:

  • synthesis and pharmacological evaluation of the biological activity of new compounds in silico and in vivo
  • biochemistry and pathobiochemistry of molecular mechanisms of biomembranes damage and therapeutico-prophylactic use of bioantioxidants
  • educational and methodological support, reformation of higher pharmaceutical education, introduction of modern educational technologies with consideration of specifics of organic, biological, pharmaceutical and toxicological chemistry for students of the Faculty of Pharmacy

 

 

Scientific themes:

 

2024-2026

  • “Study of the effect of coordination compounds of germanium and derivatives of heterocycles on the processes of cell death” Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – PhD Violetta Narokha
  • “Theoretical and methodological principles of professional training of future Masters of Pharmacy using the latest information technologies in the conditions of classroom-distance form of education” Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – Iryna But

 

2022-2025

  • “Development and improvement of methods for laboratory analysis of medical supplies (MS) and biologically active supplements (BAS) ”. Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – PharmD Olena Welchinska.

 

2021-2023

  • “Search and study of pharmacological properties of coordination compounds of germanium and derivatives of heterocycles” Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – PhD Violetta Narokha
  • “Theoretical and methodological principles of the organization of educational activities in the study of chemical disciplines by future masters of pharmacy in a mixed classroom-distance form of education” Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – Iryna But

 

2018-2020

  • «Search and study of mechanisms of action of new potential cardioprotective and antihypertensive compounds». Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – PhD Violetta Narokha
  • «Experimental rationalization for the creation of a new drug with antimicrobial and anti-inflammatory activity» Scientific supervisor MD, Prof. Iryna Nizhenkovska, responsible person – Ludmila Onyshchuk

 

DEFENDED THESIS

 

Doctor of Science (D)

 

2018

Tetyana Reva. Theoretical and methodological bases of realization of the competence approach in training of chemical disciplines of future pharmacists. Scientific consulting – MD, PhD Iryna Nizhenkovska.

 

Candidate of Sciences (PhD)

 

2024

But Iryna Methods of teaching pharmaceutical chemistry to future masters of pharmacy in the setting of classroom and distance learning. Supervisor – Prof. Iryna Nizhenkovska.

 

2021

Liudmуla Onyshchuk. Experimental justification for the creation of a new drug with antimicrobial and anti-inflammatory activity. Supervisor – Prof. Iryna Nizhenkovska.

2020

Oksana Golovchenko. Methods of organizing independent work of future masters of pharmacy in organic chemistry by means of distance learning. Supervisor – Prof. Iryna Nizhenkovska.

2019

Kateryna Matskevych. Experimental study of phosphorylated oxazole derivatives as potential antihypertensive agents. Supervisor – Prof. Iryna Nizhenkovska.

 

2018

Violetta Narokha. Experimental study of the pharmacodynamics of germanium coordination compounds in case of anthracycline intoxication. Supervisor – Prof. Iryna Nizhenkovska.

 

2017

Vitalii Pidchenko. Experimental justification of immunomodulating  ctivity and safety of fungal biomass powder of fungus GANODERMA LUCIDUM (CURT.:FR.)P.KARST». Supervisor – Prof. Iryna Nizhenkovska.

 

Publications in Scopus та Web of Science

 

2024

 

Nizhenkovska І., Afanasenko О., Nizhenkovskіу A. Adaptyvne testuvannia v farmatsevtychnii osviti: stratehii ta perevahy [Adaptive testing in pharmaceutical education: strategies and benefits]. Fitoterapiia. Chasopys – (2024). Phytotherapy. Journal, 2, 119-124. DOI: https://doi.org/10.32782/2522-9680-2024-2-119 Scopus –

 

V.P. Narokha, I.V. Nizhenkovska, O.V. Kuznetsova. Analysis of trends in physiologically based pharmacokinetic modelling in silico in translational studies of monoclonal antibodies. Biopolymers and Cell. 2024. Vol. 40. N 3. P 226-226. DOI:

http://dx.doi.org/10.7124/bc.000ACE Scopus Q4

 

Monika Sobiech, Piotr Luliński, Karol Synoradzki, Tamara J. Bednarchuk, Marta Janczura, Veronika Provorova, Joanna Giebułtowicz. Implementing magnetic molecularly imprinted solid phase extraction to analytical method for determination of 2-phenethylamine in cocoa powder and chocolate by LC-MS/MS system. Microchemical Journal, Volume 205, 2024, 111155, ISSN 0026-265X. DOI: https://doi.org/10.1016/j.microc.2024.111155. Scopus Q1

 

2023

 

Nizhenkovska, I., Kuznetsova, O., Narokha V. Intensity of endoplasmatic reticulum stress, autophagy, and apoptosis in the cerebral cortex of rats with chronic ethanol consumption under the influence of the complex compound of germanium with nicotinic acid ScienceRise: Pharmaceutical Science, No 6(46) 2023, 70-78. DOI: https://doi.org/10.15587/2519-4852.2023.295491  Scopus Q3

 

Nizhenkovska, K. Matskevych, O. Golovchenko, et al. New Prospective Phosphodiesterase Inhibitors: Phosphorylated Oxazole Derivatives in Treatment of Hypertension. Adv Pharm Bull, 2023, 13 (2). 399-407. DOI: https://doi.org/10.34172/apb.2023.044  Scopus, Q1

 

Syrotchuk О.А., Musiienko I., Didukh I.R., Nizhenkovska I.V., Glushachenko O.O. Eco-friendly HPLC method for caffeine in dietary supplement determination using ethanol-water mobile phase and PFP-column Journal of Applied Pharmaceutical Sciences Vol. 13(08), pp 151-157, August, 2023. DOI: https://doi.org/10.7324/JAPS.2023.49358  Scopus, Q2

 

2022

 

Iryna V. Nizhenkovska, Tatiana D. Reva, Oksana M. Chkhalo, Iryna O. But, Oksana V. Manchenko Best Practices for Teaching Chemistry Disciplines to Graduates Majoring in Pharmacy during the COVID-19 Restrictions: A Systematic Review. International Journal of Educational Methodology, v8 n4 p769-781 2022. DOI: https://doi.org/10.12973/ijem.8.4.769  Scopus, Q3

 

Stanislav E. Mezhov, Mihail G. Levin, Aleksei A. Gumenyuk, Natalia V. Ostanina, Olena V. Velchinska Counterfeiting dietary supplements by adding undeclared active pharmaceutical ingredients or their analogues to their composition is a new threat to the health of the population and a challenge to the national health care system Wiadomości Lekarskie Medical Advances, Vol. LXXVI, Issue 4, April 2023 p. 877. http://ir.librarynmu.com/handle/123456789/9119  Scopus, Q3

 

Narokha V.P., Nizhenkovska I.V., Kuznetsova O. V. Potential of germanium-based compounds in coronavirus infection Acta Pharm. 72 (2022) 245-258. DOI: https://doi.org/10.2478/acph-2022-0016 Scopus Q2

 

Afanasenko, O. V., Nizhenkovska, I. V., Holovchenko, O. I., & Glushachenko, O. O. (2022). Technology-enhanced constructivist learning environment for pharmacy students. Pharmacy Education, 22(1), p. 778–787.  DOI: https://doi.org/10.46542/pe.2022.221.778787 Scopus Q3

 

Korzh, I., Olieinikova, N., Beketova, M., Kubarieva, I., Korobova, Y., Sevriukov, O., & Afanasenko, O. (2022). Comparative analysis of drug consumption for the treatment of epilepsy in Ukraine, Kazakhstan and Belarus. ScienceRise: Pharmaceutical Science, (2(36), 26–36. DOI: https://doi.org/10.15587/2519-4852.2022.255840 Scopus Q3

 

2021

 

Nizhenkovska I.V., Onyshchuk L.V., Nizhenkovskyi O. I. Sensitivity of mixed cultures of microorganisms to the new combined drug in the form of pessaries. Curr Top Pharm. 25 (2021) 91-96. http://ir.librarynmu.com/handle/123456789/9769  Scopus Q4

 

Nizhenkovska IV., Reva Tetiana, Kucherenko Іnna, Stuchynska Natalia, Konovalova Liudmyla та ін. Digital Component of professional competence of Masters of Pharmacy in the framework of Blended learning Arch Pharm Pract 2021;12(1):98-102. DOI: https://doi.org/10.51847/avsEptmZsN  Scopus

 

2020

 

Nizhenkovska I.V., Matskevych K.V., Golovchenko O.V., Golovchenko O.I. The effect of OVP-1 on blood pressure and parameters of general hemodynamics in acute arterial hypertension in rabbits. Azerbaijan Pharmaceutical and Pharmacoterapy Journal. No1. 2020. P. 40-45. http://ir.librarynmu.com/handle/123456789/9130  Scopus Q4

 

Iryna Nizhenkovska, Olena Kuznetsova, Violetta Narokha. Organising distance learning for Master`s in Pharmacy in Ukraine during COVID-19 quarantine – Pharmacy Education. 2020 20(2) 59-60. DOI: https://doi.org/10.46542/pe.2020.202.5960  Scopus Q4

 

І.М. Пельо, Т.Д. Рева, І.В. Ніженковська, Н.Д. Козак, Л.Д. Коновалова Тенденції професійної підготовки фахівців із фармації в Україні. Medicni perspektivi. 2020; 25(3):4-8. DOI: https://doi.org/10.26641/2307-0404.2020.3.214543  Web of Science

 

Nizhenkovska I. V., Reva T. D., Chhalo O. M., Golovchenko O.I. Technology-Driven Self-Directed Learning of Graduate Pharmaceutists: Adding Value through Entrepreneurship  International Journal of Learning, Teaching and Educational Research. 2020. Vol. 19, No 6, рр.111- 126, June 2020. http://ir.librarynmu.com/handle/123456789/9161 Scopus Q4

 

                                                            2019

 

Tetiana Reva, Iryna Nizhenkovska, Olena Holik. Didactical aspects of professional training of future masters of pharmacy students / CBU International Conference Proceedings 2019. Vol 7 (2019). – P. 606-610. DOI: https://doi.org/10.12955/cbup.v7.1426  Web of Science

 

Welchinska Elena. The use of forensic chemistry methods in the determination of counterfeit drugs. In P. Hájek, & O. Vít (Ed.), CBU International Conference Proceedings. 7, pp. 858-863. Prague: CBU Research Institute. http://ir.librarynmu.com/handle/123456789/9407 Web of Science

 

2018

 

Nizhenkovska I., Sedko K., Kuznetsova O. Study of influence of 1,3-oxazole-4-yl-phosphonic acid derivative on nitric oxide system indicators in rats with arterial hypertension Ceska a Slovenska Farmacie. 2018. №4 (67), Р. 154-159. http://ir.librarynmu.com/handle/123456789/853  Scopus Q3

 

Iryna Nizhenkovska, Violetta Narokha, Olena Kuznetsova Effects of nicotinic acid on protein oxidative modification in experimental chronic heart failure. Farmacia, 2018, Vol. 66, 6- Р.959-962.

DOI: http://doi.org/10.31925/FARMACIA.2018.6.5  Scopus Q2

 

Nizhenkovska I., Sedko K., Golovchenko O.I., Golovchenko O.V. Efficiency of the application of the 1,3-oxazole-4-il-phosphonic acid derivative on the sustained arterial hypertension model in rats. Current Topics in Pharmacology. 2018. 22: 63-68. http://ir.librarynmu.com/handle/123456789/846 Scopus Q4

 

Nizhenkovska I.V., Zinchenko L.V. Acute toxicity study of a new complex drug with anti-inflammatory activity, Current Topics in Pharmacology. 2017; Vol. 21: 71-74. http://ir.librarynmu.com/handle/123456789/9765 Scopus Q4

 

Iryna Nizhenkovska, Nadia Gorchakova, Ganna Zaychenko, Violetta Narokha. Uracil as the basis for medication creation. Current Topics in Pharmacology. 2018. 22: 19-26. http://ir.librarynmu.com/handle/123456789/1173 Scopus Q4

 

Welchinska Elena. Halothane (2-Bromo-1,1,1-trifluoro-2-chloroethane) as example in discipline “Forensic chemistry” for Ukrainian students of pharmacy. Vol 6 (2018): CBU International Conference Proceedings 2018. Prague, Czech Republic. DOI: http://dx.doi.org/10.12955/cbup.v6.1316 Web of Science

 

 

Public activity and announcements

 

Head of the Department, MD, Professor Iryna Nizhenkovska is a head of the Formulation Committee of Ministry of Health of Ukraine; expert of the Ministry of Health of Ukraine in the field of “Pharmacy. Clinical pharmacy. Clinical pharmacology”, head of the Academic Council of the Pharmaceutical Faculty; head of the Attestation Committee for Certification of Pharmacists of the State Service for Drugs and Drug Control in Kyiv; member of the Editorial Board of Pharmaceutical Journal, Ukrainian Scientific and Medical Youth Journal and “Phytotherapy. Journal”; member of 2 specialized scientific councils: 13.00.02 – theory and methodology of teaching (medical and pharmaceutical disciplines), 15.00.01 – drug technology, organization of pharmaceutical business and forensic pharmacy; head of the cycle methodical commission in the specialty 226 “Pharmacy, Industrial Pharmacy of the Bogomolets National Medical University; member of the International Pharmaceutical Federation (FIP); academician of the National Academy of Higher Education of Ukraine; academician of the International Academy of Education of Ukraine; member of the Union of Educators of Ukraine; member of the Ukrainian Biochemical Society; Member of the European Association of Faculties of Pharmacy (EAFP); British Pharmacological Society; American Society for Pharmacology and Experimental Therapeutics.

 

Doctor of pharmaceutical sciences, Professor Olena Welchinska is a member of Editorial Board. The OA Journal of Chemistry and Materials (OAJRCJCM), United Kingdom; member of the Union of Educators of Ukraine; academician of National Academy of Sciences of Higher Education of Ukraine; academician and chief scientific secretary of International Academy of Education and Science (IAES), Ukraine; member of the International Pharmaceutical Federation (FIP).

 

D.Sc. in Biology, Professor Mykola Veliky is a member of the specialized scientific council for awarding the scientific degrees of doctor and candidate of sciences (O.V. Palladin Institute of Biochemistry of NAS of Ukraine); member of the Expert Council of the State Attestation Commission for the Expertise of the Thesis of the Ministry of Education and Science of Ukraine on biological sciences; member of the editorial board of the Ukrainian Biochemical Journal and the journal Medical and Clinical Chemistry; head of the Kyiv Department of the Ukrainian Biochemical Society; member and co-founder of the Academy of Sciences of the Higher School of Ukraine; Member of the Ukrainian branch of the scientific society EVIDAS – European Vitamin D Association Scientific society.

 

Candidate of chemical sciences, Associate Professor Olga Glushachenko, candidate of biological sciences, Associate Professor Olena Kuznetsova, candidate of pedagogical sciences, Associate Professor Oksana Golovchenko are members of the Academic Council of the Pharmaceutical Faculty; members of the Cycle methodical commission in the specialty 226 “Pharmacy, Industrial Pharmacy”.

 

PhD in Pharmacology, Associate Professor Olga Afanasenko is a Deputy Chairman of the Expert Committee «Pharmaceutical Chemistry» of the Testing Center at the Ministry of Health of Ukraine and member of the Board of Appraisal in the specialty 226 “Pharmacy” at the Bogomolets National Medical University.

 

In addition, employees of the Department are members of public organizations and professional associations of various directions:

 

  • The American Society for Pharmacology and Experimental Therapeutics (ASPET);
  • NGO «All-Ukrainian Pharmaceutical Chamber»;
  • European Association of Faculties of Pharmacy (EAFP);
  • British Pharmacological Society, BPS;
  • International Society of Pharmacometrics, ISoP;
  • Ukrainian Biochemical Society;
  • The Society of Young Scientists and Specialists of Bogomolets National Medical University;
  • NGO “International educators and scientists foundation”;

 

  • Ukrainian Association of Neurosurgeons.

 

 

Employees participate in the work of the Admission Committee of Bogomolets National Medical University.

 

 

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