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Department of Pharmacology

Scientific work

Responsible Staff Member: Doctor of Medical Sciences, Professor Nadiya Oleksandrivna Gorchakova

The rapid development of pharmacology as a science today demands new knowledge and competencies from modern academic degree seekers. Growing requirements for pharmaceutical development, as well as the quality and depth of fundamental and specific pharmacological and toxicological research, necessitate continuous professional improvement, the introduction of new assessment methods (including preclinical drug studies), fluency in European languages (particularly English), mastery of modern electronic and digital technologies, and a profound understanding of bioethics.

The foundation of academic scientific progress lies in the integration of pharmacologists with scientists from the National University of Pharmacy, institutions of the National Academy of Sciences of Ukraine (NASU), and the National Academy of Medical Sciences of Ukraine (NAMSU), including technologists, pharmacognosists, synthetic chemists, analysts, marketers, clinicians, and toxicologists. Collaborative efforts across the development process and all stages of a drug’s life cycle enhance the level of scientific research, facilitate its implementation in medical practice and pharmaceutical production, optimize experimental costs, expand interdisciplinary connections, and highlight the practical significance of obtained results.

Through the execution of scientific qualification work, young pharmacology educators develop professionally and refine their competencies, particularly in pharmacovigilance and drug safety.

During this historical period of the Department of Pharmacology at O.O. Bohomolets National Medical University, key research areas include:

  • Reproductive pharmacology
  • Pharmacology of cardiovascular drugs
  • Investigation of the pharmacological properties of nanomaterials
  • Development of dental drug forms
  • Innovations in dermatological preparations containing petroleum derivatives
  • Studies on metabolite-tropic medications
  • Research into pharmacogenetic characteristics of drugs and pharmacovigilance.

To ensure a high level of research, the department has established a laboratory for innovative pharmacological studies. Safety assessments of new drugs are a mandatory component of the research program. Within the “Pharmacovigilance” direction, postgraduate students D.O. Kozak and O.I. Dyachenko are conducting studies on pharmacovigilance in pediatrics and geriatrics. Experimental research on the efficacy and safety of new soft drug formulations based on white naphthalan oil for treating dermatological diseases, including their combinations, is being carried out by postgraduate students A.O. Horbach and I.Yu. Stan. Assistant O.O. Hrudnytska is studying the pharmacological properties of bioadhesive dental drug forms.

The experimental work of the Department of Pharmacology serves as the foundation for developing modern drug formulations, facilitating their subsequent implementation in medical practice, as confirmed by official records.

Thus, alongside academic aspects, the Department of Pharmacology at NMU actively conducts scientific research in the development of new drugs from various groups, including safety evaluations.

 

 

Scientific Laboratory of Innovative Pharmacological Research
(Address: 34 Beresteyskyi Avenue, Physico-Chemical Building, 3rd Floor, Department of Pharmacology)

 

Publishing Activities of the Department of Pharmacology
(Textbooks, Manuals, Methodological Recommendations)

Textbooks and Study Guides:

  1. Pharmacology by Rang & Dale: Vol. 1 / J.M. Ritter, R. Flower, G. Henderson, Y.K. Loke, D. MacEwan, H.P. Rang; Scientific editors of translation: H. Zaychenko, M. Khaitovych. – 9th ed. – Kyiv: Medytsyna, 2021. – 588 pages.
  2. Pharmacology by Rang & Dale: Vol. 2 / J.M. Ritter, R. Flower, G. Henderson, Y.K. Loke, D. MacEwan, H.P. Rang; Scientific editors of translation: H. Zaychenko, M. Khaitovych. – 9th ed. – Kyiv: Medytsyna, 2021. – 352 pages.
  3. Adverse Drug Reactions: A textbook for students of higher medical education institutions / I.F. Bielenichev, N.O. Gorchakova, N.V. Bukhtiyarova [et al.]; Zaporizhzhia State Medical University. – Vinnytsia: Nova Knyha, 2021. – 360 pages.
  4. Pharmacology: A textbook for students of dental faculties / I.S. Chekman, V.M. Bobyriov, N.O. Gorchakova [et al.]. – 2nd ed. – Vinnytsia: Nova Knyha, 2010. – 480 pages.
  5. Pharmacology with Fundamentals of Pathology: [Textbook] / Y.M. Kolesnyk, I.S. Chekman, N.O. Gorchakova, ., G.V. Zaychenko [et al.]. – Vinnytsia: Nova Knyha, 2021. – 472 pages.
  6. Lecture Notes: A study guide for students of higher education institutions / N.M. Kononenko, V.V. Hnatiuk, H.V. Zaychenko; Edited by N.M. Kononenko. – Kharkiv: NFaU: Zoloti Storinky, 2018. – 144 pages.
  7. Medical Prescriptions: A study guide for students of medical and pharmaceutical faculties, lecturers, doctors, pharmacists, and pharmaceutical professionals / H.V. Zaychenko, N.O. Gorchakova, N.V. Savchenko, V.Yu. Dyachenko, O.V. Shumeiko, T.V. Kava. – 3rd ed. – Kyiv: Knyha-Plus, 2021. – 72 pages.
  8. Pharmacology: A textbook for students of medical faculties / I.S. Chekman, N.O. Gorchakova, L.I. Kazak [et al.]; Edited by Prof. I.S. Chekman. – 4th ed. – Vinnytsia: Nova Knyha, 2017. – 784 pages.
  9. Pharmacology: A textbook for students of medical and dental faculties of higher medical education institutions / [I.S. Chekman, V.M. Bobyriov, V.Y. Kresyun et al.]. – Vinnytsia: Nova Knyha, 2020. – 472 pages: illustrations.

 

Reference Publications:

  1. RX-index® – Drug Equivalence Guide: [Specialized medical publication for professionals] / I.A. Zupanets, A.A. Kotvitska, V.P. Chernykh, G.V. Zaychenko [et al.]. – Kyiv: Pharmacist Praktik, 2017. – 848 pages.
  2. RX-index® – Drug Equivalence Guide: [Specialized medical publication for professionals] / I.A. Zupanets, A.A. Kotvitska, V.P. Chernykh, G.V. Zaychenko [et al.]. – 2nd ed., revised and expanded. – Kyiv: Pharmacist Praktik, 2018. – 832 pages.
  3. RX-index® – Drug Equivalence Guide: [Specialized medical publication for professionals] / I.A. Zupanets, A.A. Kotvitska, V.P. Chernykh, G.V. Zaychenko [et al.]. – 3rd ed., revised and expanded. – Kyiv: Pharmacist Praktik, 2019. – 832 pages.
  4. RX-index® – Drug Equivalence Guide: [Specialized medical publication for professionals] / I.A. Zupanets, A.A. Kotvitska, V.P. Chernykh, G.V. Zaychenko [et al.]. – 4th ed., revised and expanded. – Kyiv: Pharmacist Praktik, 2020. – 832 pages.
  5. RX-index® – Drug Equivalence Guide: [Specialized medical publication for professionals] / I.A. Zupanets, A.A. Kotvitska, V.P. Chernykh, G.V. Zaychenko [et al.]. – 5th ed., revised and expanded. – Kyiv: Pharmacist Praktik, 2021. – 832 pages.
  6. Chemotherapist’s Guide: Methodological recommendations for physicians / Compiled by: H.V. Zaychenko, T.V. Kava, O.V. Kalinchuk; Supported by: Center for Personalized Pharmacy “Chemoteka,” DoctorThinking Groups. – Kyiv; Vinnytsia: Tvoru, 2019. – 32 pages.

 

Methodological Recommendations:

  1. New Cardiovascular Drugs According to ATC Classification: Methodological recommendations / H.V. Zaychenko, N.O. Gorchakova, O.V. Shumeiko [et al.]. – Kyiv: Yuston, 2017. – 159 pages: tables.
  2. Features of Drug Pharmacodynamics in Pediatric Practice: Methodological recommendations / H.V. Zaychenko, N.O. Gorchakova, N.V. Savchenko [et al.]. – Kyiv: Yuston, 2017. – 84 pages.
  3. Features of Drug Pharmacodynamics and Prescription in Pediatric Practice: Methodological recommendations / [G.V. Zaychenko et al.]; O.O. Bohomolets National Medical University, Department of Pharmacology. – Kyiv: Yuston, 2017. – 83 pages.
  4. Innovative Approaches to Pharmacological Correction of Burn Wounds Using a Composite of Monodisperse Silica with Polyhexamethylene Guanidine Hydrochloride: Information leaflet on innovations in the healthcare system No. 211-2019 / H.V. Zaychenko, A.I. Doroshenko, N.O. Gorchakova, Ye.P. Voronin; Ukrmedpatentinform, Ministry of Health of Ukraine. – Kyiv, 2019. – 4 pages.
  5. Features of Pharmacodynamics and Prescription of Drugs Affecting the Respiratory System: Educational-methodical guide for 3rd–4th year medical students / I.F. Belenichev, H.V. Zaychenko, N.O. Gorchakova [et al.]. – Zaporizhzhia; Kyiv, 2019. – 122 pages.
  6. Method for Treating Prostate Diseases Using a Combination of Indole-3-Carbinol and Meloxicam: Information leaflet on innovations in the healthcare system No. 141-2019 / H.V. Zaychenko, O.A. Ruban, T.B. Ravshanov [et al.]; Ukrmedpatentinform, Ministry of Health of Ukraine. – Kyiv, 2019. – 4 pages.
  7. Clinical-Pharmacological Characteristics of Modern Antimicrobial Agents: Educational-methodical guide for 3rd–4th year medical students / I.S. Chekman, I.F. Belenichev, N.V. Bukhtiyarova [et al.]. – Zaporizhzhia: ZDMU, 2019. – 111 pages.
  8. Acute Poisoning with Drugs: Diagnosis and Emergency Therapy Methods:F. Belenichev, O.A. Nagorna, N.V. Bukhtiyarova, N.O. Gorchakova, S.A. Morguntsova, L.I. Kucherenko, O.V. Khromilova. – Zaporizhzhia, 2019. – 102 pages.

 

Information Bulletins:

  1. Use of Peach Leaf Extract as a Cytokine Modulator in the Complex Therapy of Infectious and Inflammatory Diseases: Information bulletin No. 102 from April 19, 2017 / H.V. Zaychenko, O.Ya. Mishchenko, Kh.Sh. Sharifov [et al.]; Ukrmedpatentinform, Ministry of Health of Ukraine. – Kyiv, 2017. – 4 pages.
  2. Improvement of the Experimental Method for Reproducing Acute Anal Fissure: Information bulletin / H.V. Zaychenko, M.O. Stakhorska, M.O. Lyapunov, O.V. Faizullin; Ukrmedpatentinform, Ministry of Health of Ukraine, EPC “Pharmacy” Decision, Protocol No. 103 from October 25, 2017. – Kyiv, 2017. – 3 pages.
  3. Method of Using Cream with Cerium Dioxide Nanoparticles for Preventing UV Radiation Damage: Information bulletin No. 303-2018 / H.V. Zaychenko, O.A. Pokotylo, P.V. Simonov, O.A. Kachalova; Ukrmedpatentinform, Ministry of Health of Ukraine. – Kyiv, 2018. – 3 pages.
  4. Innovative Approaches to Pharmacological Correction of Burn Wounds Using a Composite of Monodisperse Silica with Polyhexamethylene Guanidine Hydrochloride: Information bulletin on healthcare system innovations No. 211-2019 / H.V. Zaychenko, A.I. Doroshenko, N.O. Gorchakova, Ye.P. Voronin; Ukrmedpatentinform, Ministry of Health of Ukraine. – Kyiv, 2019. – 4 pages.
  5. Method for Treating Prostate Diseases Using a Combination of Indole-3-Carbinol and Meloxicam: Information bulletin on healthcare system innovations No. 141-2019 / H.V. Zaychenko, O.A. Ruban, T.B. Ravshanov [et al.]; Ukrmedpatentinform, Ministry of Health of Ukraine. – Kyiv, 2019. – 4 pages.

 

Monographs:

  1. Premature Childbirth: Fundamental and Clinical Aspects: Monograph / A.O. Shevchenko, I.F. Belenichev, A.D. Kyryliuk [et al.]. – LAP LAMBERT Academic Publishing, 2022. – 308 pages.
  2. Medical Toxicology: Preclinical Studies; Edited by Academician of NAMN and Corresponding Member of NAS of Ukraine I.M. Trachtenberg. – Kyiv: Avicenna Publishing House, 2019. – 544 pages.

Patents:

  1. Patent No. 115476 C2 Ukraine: Pharmaceutical composition in the form of suppositories (pessaries) for the treatment and prevention of the genital form of herpesvirus infection / Yu.V. Levachkova, O.M. Lytvinova, V.V. Chernykh, G.V. Zaychenko [et al.]; Applicant and patent holder: National Pharmaceutical University. – Application No. a201511571; filed on 23.11.2015; published on 10.11.2017, Bulletin No. 21. – 6 pages.
  2. Patent No. 124891 Ukraine: Method for determining the acute toxicity of a composite of nanodisperse silica and polyhexamethylene guanidine hydrochloride / I.S. Chekman, Ye.P. Voronin, A.I. Doroshenko, A.M. Doroshenko; Applicant and patent holder: O.O. Bohomolets National Medical University. – Application No. u201711217; filed on 16.11.2017; published on 25.04.2018.
  3. Patent No. 124890 Ukraine: Method for determining the antimicrobial activity of a composite of nanodisperse silica and polyhexamethylene guanidine hydrochloride / I.S. Chekman, O.B. Balko, Ye.P. Voronin, A.I. Doroshenko, A.M. Doroshenko; Applicant and patent holder: O.O. Bohomolets National Medical University. – Application No. u201711216; filed on 16.11.2017; published on 25.04.2018.
  4. Patent No. 131416 Ukraine: Use of a derivative of 1,3-oxazol-4-yl-phosphonic acid as an antihypertensive agent / O.I. Holovchenko, I.V. Nizhenkovska, G.V. Zaychenko [et al.]; Applicant and patent holder: O.O. Bohomolets National Medical University. – Application No. u201808311; filed on 27.07.2018; published on 10.01.2019.
  5. Patent No. 134165 Ukraine: Pharmaceutical composition in the form of suppositories for the treatment of benign prostatic diseases / V.S. Zaychenko, O.A. Ruban, G.V. Zaychenko [et al.]. – Application No. u201810110; filed on 10.10.2018; published on 10.05.2019, Bulletin No. 9.
  6. Patent No. 135187 Ukraine: Multi-purpose pharmaceutical composition in the form of a dental gel / Yu.S. Masliy, O.A. Ruban, H.V. Zaychenko, O.O. Hrudnytska. – Application No. u201812406; filed on 13.12.2018; published on 25.06.2019, Bulletin No. 12.
  7. Patent No. 135665 Ukraine: Pharmaceutical composition for the treatment of proctological diseases / I.A. Vyshnevskyi, M.O. Lyapunov, G.V. Zaychenko [et al.]; Applicant and patent holder: I.A. Vyshnevskyi. – Application No. u201901255; filed on 07.02.2019; published on 10.07.2019.
  8. Patent No. 139105 Ukraine: Pharmaceutical composition for correcting hypoestrogenic conditions in women in the form of vaginal gel / O.I. Ivanyuk, T.H. Yarnykh, G.V. Zaychenko [et al.]; Applicant and patent holder: National Pharmaceutical University. – Application No. u201905153; filed on 15.05.2019; published on 26.12.2019, Bulletin No. 24.
  9. Patent No. 122021 C2 Ukraine: Multi-purpose pharmaceutical composition in the form of a dental gel / Yu.S. Masliy, O.A. Ruban, H.V. Zaychenko, O.O. Hrudnytska; Applicant and patent holder: National Pharmaceutical University. – Application No. a201812408; filed on 13.12.2018; published on 25.08.2020.
  10. Patent No. 122714 C2 Ukraine: Pharmaceutical composition in the form of suppositories for the treatment of benign prostatic diseases / V.S. Zaychenko, O.A. Ruban, G.V. Zaychenko [et al.]; Applicant and patent holder: National Pharmaceutical University. – Application No. a201810112; filed on 10.10.2018; published on 28.12.2020, Bulletin No. 24. – 5 pages.