Bogomolets National Medical University
HONOR, MERCY, GLORY

Department of Internal Medicine №4

SCIENTIFIC WORK

 

Responsible for scientific work:

Altunina NV – d. med.science, Associate Professor of Internal Medicine №4,

phone +380509209139

Email address – alt.nataliia77@gmail.com

 

The priority areas of scientific work of the Department of Internal Medicine №4 are the following sections of modern cardiology, rheumatology and internal medicine:

  • Obstructive sleep apnea syndrome: connection with cardiovascular diseases
  • The state of activity of the dopaminergic system as one of the factors in the development of hypertension and obesity
  • The role of disorders of humoral and cellular immunity in the development of atherosclerosis and acute coronary syndrome
  • Prediction of unstable angina by studying the fatty acid spectrum of platelets
  • Features of diagnosis and treatment of coronary heart disease in patients with concomitant pancreatitis
  • Postrandial hypotension, mechanisms of development, diagnosis, treatment
  • Treatment of pulmonary hypertension in patients with diabetes mellitus
  • Obesity – a risk factor for hyperinsulinemia in patients with essential hypertension
  • The role of disorders of the fatty acid spectrum of lymphocytes in the development of coronary heart disease
  • Imbalance of amino acid composition of blood plasma as a possible pathogenetic link in the development of atherosclerosis and coronary heart disease
  • Treatment of systolic heart dysfunction in patients with type 2 diabetes mellitus who have suffered non-Q-myocardial infarction
  • Determination of changes in blood lipid spectrum in postinfarction patients with type 2 diabetes mellitus
  • Determination of zinc content in the blood of patients with type 2 diabetes who have suffered a myocardial infarction
  • Drug correction of disorders of fatty acid spectrum of erythrocyte membranes in patients with persistent atrial fibrillation
  • Long-term hyperinsulinemia in patients with hypertension and metabolic disorders
  • Treatment of cardiac arrhythmias in postinfarction patients with type 2 diabetes
  • Treatment of degenerative-dystrophic diseases of the spine
  • The state of the intestinal microbiota in patients with coronary heart disease with paroxysmal atrial fibrillation
  • The role of disorders of tryptophan and serotonin metabolism in patients with generalized atherosclerosis
  • ASA-induced gastropathies in patients with high cardiovascular risk.

 

In recent years, scientists of the department have conducted and continue to conduct research on the following topics:

  • Use of pemafibrate to reduce cardiovascular complications by lowering triglycerides in patients with diabetes mellitus)
  • Open-label phase 3b study to evaluate the long-term safety and efficacy of vedolizumab for subcutaneous administration in patients with ulcerative colitis and Crohn’s disease
  • Impaired hemodynamics, coronary circulation and ectopic myocardial activity in patients with coronary heart disease with concomitant diabetes mellitus, methods of drug correction
  • Long-term study of the effects to assess the reduction of residual risk with statin in combination with Epanov in patients with high cardiovascular risk hypertriglyceridemia (“STRENGTH”)
  • Changes in the amino acid spectrum of blood plasma in patients with coronary heart disease with cardiac arrhythmias and their drug correction
  • Influence of serum amino acid spectrum in type 2 diabetes mellitus on cardiovascular risk indicators in patients with coronary heart disease and methods of drug correction
  • Features of the course of unstable angina depending on the functioning of the hemostasis system in different variants of statin therapy
  • Clinicopathogenetic justification for the use of cilostosol in patients with complicated hypertension
  • Comprehensive assessment of hemodynamic and metabolic disorders in patients with coronary heart disease combined with type II diabetes mellitus and possible drug correction.
  • Violation of the fatty acid spectrum of platelets, immunological status and amino acid spectrum of blood serum and the possibility of drug correction)
  • Changes in the fatty acid spectrum of erythrocyte membranes with a constant form of atrial fibrillation
  • Disorders of lipid, carbohydrate and protein metabolism in patients with coronary heart disease with concomitant hypertension, the possibility of drug correction

All scientific and pedagogical employees of the department take an active part in research work. According to the results of scientific research during 2015-2021, the staff of the department made more than 140 reports at scientific congresses, symposia and conferences, including foreign ones, published more than 120 scientific articles and abstracts in scientific journals.