Department of Internal Medicine with a Course in Gastroenterology

Scientific work

Research Activities of the Department

Responsible staff members: Associate Professor Artem Valeriiovych Neverovskyi, and Assistant Lecturer Vladyslav Anatoliiovych Tovstyha.

Since 2018, the Department has been conducting planned research activities focused on the prevention, diagnosis, and treatment of gastrointestinal diseases under conditions of comorbidity.

Research topic (until 2025) – former Department of Internal Medicine No. 1:
“Study of clinical and pathogenetic relationships in comorbid digestive system diseases and conditions and improvement of treatment approaches”,
State Registration No. 0123U100922.

Research topic – former Department of Internal Medicine No. 4:
“Features of lipid, protein, neurotransmitter metabolism and hemodynamics in patients with generalized atherosclerosis and secondary prevention of cardiovascular events.”

All members of the Department are involved in the implementation of the research projects.

Priority research areas – former Department of Internal Medicine No. 1:

• Study of the prevalence of major gastrointestinal diseases in patients with cardiovascular, endocrine, hematological, and nephrological disorders;
• Investigation of intestinal microbiota to develop methods for correcting lipid and carbohydrate metabolism in patients with type 2 diabetes mellitus and metabolic syndrome, as well as for controlling cardiovascular risk;
• Study of genetic polymorphisms in patients with metabolic syndrome and obesity and development of personalized dietary models;
• Development of modern, effective diagnostic tests for type 2 diabetes mellitus based on ceramide analysis;
• Study of current issues in the diagnosis and treatment of coagulopathies in liver cirrhosis in the presence of comorbid cardiovascular pathology;
• Development and implementation of endoscopic treatment methods for gastrointestinal diseases.

The Department is actively working on the implementation of non-invasive diagnostic methods for gastrointestinal diseases and on developing new personalized approaches to the prevention and treatment of obesity and metabolic syndrome.

Priority research areas – former Department of Internal Medicine No. 4:

• Diagnosis and treatment of patients with comorbid internal organ pathology;
• Plasma amino acid imbalance as a possible pathogenetic factor in the development of atherosclerosis and coronary heart disease;
• Treatment of cardiac arrhythmias in post-myocardial infarction patients with type 2 diabetes mellitus;
• Features of treatment in patients with generalized atherosclerosis;
• Composition of intestinal microbiota in patients with coronary heart disease and paroxysmal atrial fibrillation;
• Role of tryptophan and serotonin metabolism disorders in patients with generalized atherosclerosis;
• Role of humoral and cellular immune disturbances in the development of atherosclerosis and acute coronary syndrome;
• Prognosis of unstable angina based on analysis of the fatty acid spectrum of platelets;
• Features of diagnosis and treatment of coronary heart disease in patients with concomitant pancreatitis;
• Role of fatty acid spectrum disturbances of lymphocytes in the development of coronary heart disease;
• Activity of the dopaminergic system as a factor in the development of arterial hypertension and obesity;
• Treatment of systolic heart dysfunction in patients with type 2 diabetes mellitus after non–Q-wave myocardial infarction;
• Assessment of changes in the lipid profile in post-myocardial infarction patients with type 2 diabetes mellitus;
• Pharmacological correction of fatty acid spectrum disorders of erythrocyte membranes in patients with permanent atrial fibrillation;
• Impact of hyperinsulinemia on long-term prognosis in patients with arterial hypertension and metabolic disorders;
• Disorders of lipid, carbohydrate, and protein metabolism in patients with coronary heart disease and concomitant arterial hypertension and possibilities for pharmacological correction.

Publishing Activities

Textbooks, Educational Manuals, and Monographs Published with the Participation of Staff of the Former Department of Internal Medicine No. 4:

• Methodological Guidelines for Practical Classes for 4th-Year Students of Higher Medical Education Institutions. Content Module 3 “Pulmonology.” Kyiv, 2024. 89 pp.
  (Lyzohub V.G., Kramarova V.N., Tkachyshyn V.S., Yaremenko O.B., Dobrianskyi D.V., Sharaieva M.L., Dolynna O.V., Chychula Yu.V., Melnychuk I.V., Motsak T.M., Bielikova Y.O., Savchenko O.V., Bondarchuk O.M., Tyravska Y.V., Halich V.-S.M., Kuzmenko L.A., Novyk D.S.)
• Unified Guidelines (for Departments of Internal Medicine No. 1–4) for pulmonology practical classes for 4th-year international students within the educational discipline “Internal Medicine, including Endocrinology.”
  Lyzohub V.G., Professor, MD, PhD; Shypulin V.P., Professor, MD, PhD; Cherniavskyi V.V., Professor, MD, PhD; Plyskevish, PhD; Sharaieva M.L., PhD; Moshkovska Y.O., PhD; Melnychuk I.O., PhD; Bielikova Y.O., PhD; Krushynska N.A., PhD; Motsak T.M., PhD; Tyravska Y.V., PhD; Kuzmenko L.A., Halich V.M.
  Kyiv, 2025.
• Unified Guidelines (for Departments of Internal Medicine No. 1–4) for hematology practical classes for 4th-year international students within the educational discipline “Internal Medicine, including Endocrinology.”
  Kyiv: MEDPRINT, 2022. 100 pp. ISBN 978-966-2711-54-7.
• Unified Methodological Recommendations (for Departments of Internal Medicine No. 1–4) in Hematology for 4th-year students within the educational discipline “Internal Medicine, including Endocrinology.”
  Kyiv: MEDPRINT. 100 pp. ISBN 978-966-2711-53-0.
• Hyshchak T.V., Dolynna O.V. Fundamentals of Medical Knowledge and Tactical Medicine: Educational Manual.
  Kyiv: Karavela Publishing House, 2024. 284 pp. ISBN 978-966-8019-48-7.
• Kraidashenko O.V., Kupnovetska I.H., Klishch I.N., Lyzohub V.G. Textbook for students of the Faculty of Pharmacy. 2nd edition.
  Vinnytsia: Nova Knyha, 2018. 644 pp., illustrated. ISBN 978-966-382-486-4.
• Lyzohub V.G., Bohdan T.V., Sharaieva M.L., Kraidashenko O.V., Voloshyna O.O. Adverse Drug Reactions: Educational Manual.
  Kyiv, 2013. 137 pp.
• Cardiovascular Diseases. Classification, Standards of Diagnosis and Treatment.
  All-Ukrainian Association of Cardiologists; edited by V. M. Kovalenko et al. 3rd revised and expanded edition.
  Kyiv: Morion, 2023. 221 pp., illustrations and tables.
  Library code: NNMU Library B-98221.