Bogomolets National Medical University
HONOR, MERCY, GLORY

DEPARTMENT OF MODERN TECHNOLOGIES OF MEDICAL DIAGNOSTICS AND TREATMENT

Scientific work

The staff of the department is actively involved in scientific work. The research is performed on the basis of the Research Institute of Experimental and Clinical Medicine.

 

From the materials of the report of 2019

The list of research performed in the department

 

Theme code

(applied, fundamental)

№ state registration Name of the scientific research work (SRW) Deadlines SRW leaders Responsible performers
SRW financed by the Ministry of Health of Ukraine from the State Budget
1. Applied SRW 0118U001214 To study the importance of genetic factors and external influences on the development and progression of microcirculatory complications in type 2 diabetes 2018-2020 Natrus LV Panova TI
2. Applied SRW 0118U001218 Improving methods of diagnosis, treatment and secondary prevention of complications in patients with metabolic syndrome and gout based on the study of the type of immune response, the activity of adhesion and aggregation of immunocompetent cells and the functional state of the endothelium 2018-2020 Natrus LV,

Kondratyuk VE

Maltsev DV
3. Fundamentally Study of cell-molecular mechanisms of pharmacological influence on the reprogramming of the functional phenotype of macrophages in wound regeneration on the background of hyperglycemia 2019-2021 Natrus LV Panova TI
4. Fundamentally Structural and functional changes of neurons of the medio-basal hypothalamus in disorder of carbohydrate and lipid metabolism 2019-2021 Tchaikovsky Yu.B. Natrus LV
SRW financed on the basis of economic agreements, including clinical trials
1. № 253 Clinical trials of allergy blot “Respiratory profile” 2019 Natrus LV Maltsev DV
2. № 273 Clinical trials of allergological blot “Food profile 1” “Multiplex” 2019-2020 Natrus LV Maltsev DV

 

 

Information on received grants

The name of Grant sponsor Grant receiver (surname, initials) Grant purpose Grant effectiveness (for example: participation in a conference)
1. Octapharma AG Bogomolets National Medical University Study “Effectiveness of Octaplas replacement therapy for primary leucine deficiency (MBL) of mannose” The effectiveness of Octaplas replacement therapy for primary leucine deficiency (MBL) of mannose in patients has been studied

 

List of applications for inclusion of a scientific report in the List of scientific (scientific and technical) products intended for the implementation of medical science achievements in the field of health care in the reporting year and monitoring of the implementation of scientific products for 3 years

Name of innovation (registration №) Name of clinical unit or laboratory (developer) Healthcare facilities where innovations have been implemented for 3 years Implementation efficiency (medical, economic, social)
1. Information sheet “Method of assessing the state of platelet hemostasis for reconstructive treatment with enriched with growth factors plasma according to the method of PRGF ENDORET” Research Institute of Experimental and Clinical Medicine 2018 – Department of Surgical Dentistry of the Dental Medical Center (implementation act dated 19.11.2018),

Kyiv City Clinical Ambulance Hospital: Department of Neurosurgery (implementation act dated 19.11.2018)

Implemented in specialized health care facilities (regional, city, district), maxillofacial surgery and dentistry for post-traumatic and postoperative defects and reconstructive treatment.
2. Guidelines

The method of using enriched with growth factors plasma according to the method of PRGF EndoRet, taking into account the assessment of platelet hemostasis.

Research Institute of Experimental and Clinical Medicine 2018 – Department of Surgical Dentistry of the Dental Medical Center (implementation act dated 19.11.2018),

Kyiv City Clinical Ambulance Hospital: Department of Neurosurgery (implementation act dated 19.11.2018)

For implementation in institutions of maxillofacial surgery and stomatology concerning posttraumatic and postoperative defects and reconstructive and restorative treatment
3. Protocol of clinical trials on the effectiveness, sensitivity, specificity and safety of medical devices (hereinafter – VMP): A set of reagents for the determination of IgE antibodies to respiratory allergens in human serum (plasma), “Respiratory profile” manufactured by Limited Liability Company “Product SEVEN », Ukraine Research Institute of Experimental and Clinical Medicine 2019 – clinical diagnostic laboratories to improve diagnostic approaches in the field of allergy diagnostics. Medical device: A set of reagents for the determination of IgE antibodies to respiratory allergens in human serum (plasma), “Respiratory profile” produced by Limited Liability Company “Production Company SIMESTA” (Ukraine) does not require additional research, laboratory characteristics (parameters) meet requirements for their use in medical and diagnostic practice and are not inferior in quality to analogues of leading European manufacturers approved for use in Ukraine. The product can be used in the medical industry of Ukraine.
4. Protocol of clinical trials on the effectiveness, sensitivity, specificity and safety of medical devices (hereinafter – VMP): A set of reagents for the determination of IgE antibodies to respiratory allergens in human serum (plasma), “Food Profile 1” produced by the Limited Liability Company “Production SIMESTA company », Ukraine Research Institute of Experimental and Clinical Medicine 2019 – clinical diagnostic laboratories to improve diagnostic approaches in the field of allergy diagnostics. Medical device: A set of reagents for the determination of IgE antibodies to respiratory allergens in human serum (plasma), “Respiratory profile” produced by Limited Liability Company “Production Company SIMESTA” (Ukraine) does not require additional research, laboratory characteristics (parameters) meet requirements for their use in medical and diagnostic practice and are not inferior in quality to analogues of leading European manufacturers approved for use in Ukraine. The product can be used in the medical industry of Ukraine.

 

Key publications in 2020

  1. Natrus L.V., Ryzhko I.M., Lisakovskaya O.O., Tikhomirov A.O., Labudzynsky D.O., Panova T.I. The role of NF-κB in the differentiation and activation of neutrophils during the healing of burn wounds in the skin of rats. Physiol. magazine. 2019; 65 (6): 94-105. DOI: https://doi.org/10.15407/fz65.06.094
  2. Natrus L.V., Gayova L.V., Byhovets M.Yu., Osadchuk Yu.S., Konovalov S.E. The value of regulatory effects on lipid metabolism in during complicated diabetes mellitus. Fiziol. Zh. 2020; 66(1): 25-34. DOI: https://doi.org/10.15407/fz66.01.025
  3. Brodetska, L., Natrus, L., Lisakovska, O. et al. The regulatory role of the RANKL/RANK/OPG signaling pathway in the mechanisms of tooth eruption in patients with impacted teeth. BMC Oral Health 20, 261 (2020). https://doi.org/10.1186/s12903-020-01251-y
  4. O. Rykov, L.V. Natrus, M.Iu. Bykhovets. PPARγ-mediated differences in energy substrate among T2DM patients differing in the stage of diabetic retinopathy . Journal of Ophthalmology (Ukraine) – 2019 – Number 6 (491) http://www.ozhurnal.com/sites/default/files/2019-6-2.pdf
  5. Labudzynskyi D. O., Shymanskyi I. O., Lisakovska O. O., A. O. Mazanova, Natrus L. V., Veliky M. M. Vitamin D(3) regulates hepatic VEGF-A and apelin expression in experimental type 1 diabetes. Ukr.Biochem.J. 2020; Volume 92, Issue 4, Jul-Aug, pp. 5-13. http://ukrbiochemjournal.org/2020/09/vitamin-d3-regulates-hepatic-vegf-a-and-apelin-expression-in-experimental-type-1-diabetes.html
  6. Maltsev D., Natrus L. The Effectiveness of Infliximab in Autism Spectrum Disorders Associated with Folate Cycle Genetic Deficiency. Psychiatry, psychotherapy and clinical psychology, 2020, Vol 11, (3). Р 581-592. DOI 10.34883/PI.2020.11.3.015 (the article is in print)