Кабінет студента
Home/General Information/Departments/Department of physiology/SCIENTIFIC WORK

Department of physiology

SCIENTIFIC WORK

Responsible person

Tarasova Kateryna, PhD, Associate professor, flokalin1@gmail.com.

 

Research Activities

Departmental Repository

Department of Physiology Repository:
http://ir.librarynmu.com/handle/123456789/123

 

Research Project of the Department of Physiology (2024–2026)

“Features of Ovarian Function under Experimental Hyperglycemia and the Use of Gold Nanoparticles”

Project Leader:
Head of Department, PhD in Medicine, Associate Professor Ihor Karvatskyi

Responsible Researchers:

 

Aim of the Study

To evaluate the effect of different concentrations of gold nanoparticles (GNPs) on the reproductive function of female mice under conditions of experimental hyperglycemia.

 

Research Objectives

  1. To investigate the reproductive function of female mice under experimental hyperglycemia, specifically determining the proportions of viable and apoptotic, necrotic, and autophagic cells in the follicular environment of oocytes.
  2. To study the effects of antioxidants (vitamins A and C) on ovarian cell function.
  3. To assess the influence of gold nanoparticles D‑g‑PAA(PE)/AuNP (0.10 μM, 1.0 μM, 10.0 μM) and AuNPs (ALDRICH) (1.0 μM and 10.0 μM) on reproductive function, including the proportions of viable and apoptotic, necrotic, and autophagic follicular cells.

 

Scientific Novelty

  1. For the first time, the effects of gold nanoparticles on the reproductive function of female mice under experimental hyperglycemia will be investigated.
  2. A comparative analysis of the effectiveness of different concentrations of gold nanoparticles on reproductive outcomes will be conducted.

 

Practical Significance

The planned research—evaluating the impact of GNP administration on oocytes, follicular cells, and pre‑ and post‑implantation embryonic mortality in mice—may facilitate the translation of gold nanotechnology into clinical practice.
The results are expected to contribute to the development of safe, cost‑effective, and environmentally friendly GNP‑based therapeutic agents, as well as to a deeper understanding of their mechanisms of action under experimental conditions.

The findings will be used:

  • in the educational process at the Department of Physiology,
  • in preclinical studies at the O.O. Bohomolets Institute of Physiology,
  • in healthcare practice within specialized medical institutions.

 

Research Timeline

  • December 2023— Project planning
  • 2024— Study of ovarian cell function under experimental hyperglycemia
  • 2025— Study of the effects of antioxidants (vitamins A and C) on ovarian cell function
  • 2026— Study of the effects of different concentrations of gold nanoparticles on ovarian cells (oocytes) in vitro

 

  • Main directions of workin 2017-2020 arethe following: the methods of cardiovascular system`s studying, theregulationofmembraneandmitochonrialchannels of cardiomyocytes, age peculiarities of functioning of cardiomyocytes and the cells of smooth muscles of vessels.
  • Researchwork

Scientificresearchwork, whichhasbeenscheduledfor 2017-2020:“The research of membrane and intracellular regulatory mechanisms of cardiomyocytes and smoothmuscular cells` activity under different functional states”.

  • Thescientificresearchwork, whichwasfulfilledin 2019:«Thestudyofmembranemechanismsof arterial pressure regulation and electric processes in myocardium»

Monograph:

  1. LiudmylaKlymenko, History of formation and development of Kyiv physiological schools (end of XIX century – XX centuries). – K.: Phytocenter, 2017. – 271 p.
  2. Publishingactivities in 2019.
  3. Фізіологія. За редакцією І.М.Карвацького. Навчальний посібник до практичних занять і самостійної роботи студентів. У 2-х томах. ‒ К.: Фенікс, 2019. Т.1 – 352 с.
  4. Практикум по физиологии. ПодредакциейИ.Н.Карвацкого. Пособие к практическимзанятиям и самостоятельнойработеиностранныхстудентов с русскимязыкомобучения. В 2-х томах. ‒ К.: Феникс, 2019. Т.1 – 278 с.
  5. Practicalworksinphysiology. EditedbyI.M.Karvatsky. TextbookforpracticalstudiesandindividualworkforEnglish-speakingstudents. 2-th Vol. – Kyiv. Phoenix, 2019. V.1 – 296 p.

In 2019, 4 articleswerepublishedinScopusindexedJournals, 5 articlesinprofessional Journals of SAC of the Ministry of Science and education, 2 articles in other publications.