Bogomolets National Medical University
HONOR, MERCY, GLORY

Department of Internal Medicine №2

Scientific work

Responsible for scientific work: Dr. med. Prof. Rudenko Yu.V.

Priority directions of scientific work of the department of internal medicine №2 are sections of modern cardiology, rheumatology and internal medicine:

  1. Pathology of vessels of pulmonary circulation
  • Clinical and instrumental diagnostics and treatment of idiopathic pulmonary hypertension
  • Clinical and instrumental diagnostics and treatment of thromboembolism of pulmonary artery branches and postthrombotic pulmonary hypertension
  • Chronic pulmonary heart
  • Peculiarities of diagnosis and treatment of coronary heart disease in patients with chronic obstructive pulmonary disease
  • Possibilities of therapeutic treatment of congenital heart disease in adults
  1. Pathophysiological mechanisms of development, diagnosis and treatment of acute coronary syndrome
  • Disorders of myocardial perfusion in patients with acute coronary syndrome with elevate ST segment after primary coronary interventions
  • Early systolic dysfunction of the left ventricle in patients with Q-myocardial infarction: pathophysiological mechanisms, features of remodeling and efficacy of treatment including beta-blockers
  • Clinical features, changes of systolic and diastolic left ventricular function and treatment of myocardial infarction with Q wave in older patients
  • The mechanism of occurrence, variants and prognosis of early postinfarction angina in patients with acute myocardial infarction
  • The influence of the dose of statins in terms of their effectiveness in patients with acute coronary syndrome without elevation of ST segment
  • Variants of the clinical course and changes of the morphofunctional state of the heart in patients with myocardial infarction of posterior wall of the left ventricle with destruction of the right ventricle
  • Aspirin resistance influence on the clinical course and the indices of platelet and plasma hemostasis in patients with acute coronary syndrome without elevation of ST segment
  1. The impact of systemic inflammation on atherosclerosis in diseases of connective tissue
  2. Pathophysiological mechanisms, diagnosis and treatment of acute and chronic heart failure of different genesis with reduced and preserved ejection fraction of the left ventricle
  3. Drug prevention of stroke and cardiovascular complications in patients with arterial hypertension
  4. The condition of the musculoskeletal system and arterial stiffness in patients with rheumatic diseases and diseases of the cardiovascular system

 

Scientists of the department conducted and continue to conduct research in the following topics over the past years:

  1. Biochemical mechanisms of regulation of endothelial function in patients with different variants of heart failure (2005-2008)
  2. Optimization of treatment and rehabilitation of patients with acute myocardial infarction through the development and implementation of complex prevention of early and late complications (2009-2011)
  3. Pathophysiological mechanisms and new approaches to the treatment of various clinical forms of chronic heart failure (2011-2015)
  4. The latest technology of medical and surgical stroke prevention and cardiovascular complications in patients with atherosclerotic lesions of different vascular branches (2014 – 2016)
  5. New methods of diagnostics and prevention of cardiovascular complications in patients with different clinical forms of heart failure (2016 – 2019)
  6. New pathogenetic approaches to the diagnosis of heart failure with preserved ejection fraction of the left ventricle (2016 – 2019)
  7. The study of the state of locomotor apparatus, indices of central arterial pressure and the velocity of propagation of pulse wave in patients with rheumatic diseases and diseases of the cardiovascular system (2016 – 2019)
  8. Structural and functional features of the vessels and of the myocardium, the skeletal system in patients with rheumatic diseases and diseases of the cardiovascular system (2020-2022)

 

The research work involves active participation of all teaching staff of the department. According to the results of scientific studies during 2015-2019 years, the department staff made more than 130 presentations at scientific congresses, symposium and conferences, including foreign ones, published more than 100 scientific articles and abstracts in scientific journals. The department performed 2 doctoral and 7 PhD scientific works for 2015-2019 years.

 

Reports of the staff of the department of Internal Medicine №2 at foreign scientific forums (2015-2018)

  1. К.М.Амосова, К.П. Лазарева, П.О.Лазарев Ю.В.Руденко. Effect of calcium channel blocker and different renin-angiotensin-aldosterone system inhibitors on pulse wave analysis indices in mild-moderate uncomplicated hypertensives. 26th Meeting of the European Society of Hypertension Paris, France,. June 10-13, 2016
  2. К.М.Амосова, Ю.В.Руденко. Assessment of uncomplicated hypertension therapy effectiveness in real life setting: home blood pressure self-measurement as an alternative to ambulatory 24-hour monitoring. 26th Meeting of the European Society of Hypertension Paris, France,. June 10-13, 2016
  3. К.М.Амосова, Ю.В.Руденко. Prevalence of true resistant hypertension in uncomplicated hypertensives with apparent treatment resistant hypertension in longitudinal real-life study. 26th Meeting of the European Society of Hypertension Paris, France,. June 10-13, 2016
  4. К.М.Амосова, Ю.В.Руденко. Effect of algorithmized antihypertensive treatment at masked uncontrolled hypertension persistence in uncomplicated hypertensives. ESC Congress 2016 Rome, Italy August 27, 2016 – August 31, 2016
  5. Amosova, A. Bezrodny, I. Gorda, I. Katsytadze, Y. Sychenko, I. Prudkiy, A. Sablin, N. Melnychenko, S. Bogdan, O. Hodakivska Comparative effects of “nitrate centered” and “diuretic centered” treatment of acute decompensated heart failure on clinical congestion, NT-pro-BNP and tissue doppler parameters. ESC Acute Cardiovascular Care 2015, Geneva, Switzerland,18-20 October 2015
  6. Amosova, A. Bezrodny, I. Gorda, A. Sablin, N. Melnychenko, S. Bogdan, O. Hodakivska, G. Mostbauer, I.Kovaleva, P. Lazarev, I. Prudkiy, I. Katsytadze, Y. Sychenko, O. Vasilenko, K. Chernyaeva. Early acute renal tubular damage during decongestive therapyof acute decompensated heart failure. ESC Congress 2016, Rome, Italy, August 27, 2016 – August 31, 2016
  7. Amosova, I. Prudkyi, I. Katsytadze, O. Gerula Evaluating the long-term effectiveness of Levosimendan use on the quality of life in patients with advanced heart failure. ESC Acute Cardiovascular Care 2015, Geneva, Switzerland, 18-20 October 2015
  8. Amosova, A. Bezrodny, I. Gorda, I. Katsytadze, Y. Sychenko, I. Prudkiy, A. Sablin, N. Melnychenko, S. Bogdan, O. Hodakivska Comparative effects of “nitrate centered” and “diuretic centered” treatment of acute decompensated heart failure on clinical congestion, NT-pro-BNP and tissue doppler parameters ESC Acute Cardiovascular Care 2015, Geneva, Switzerland, 18-20 October 2015
  9. Gorda I. Markers of acute kidney injury in patients with acute decompensated heart failure in the assessment methods decongestion. ESC CONGRESS 2017, Barcelona, Spain, August 26-30, 2017
  10. К.М. Амосова, Ю.В.Руденко. Effect of standardized algorithmic treatment on home blood pressure variability: gender differences in longitudinal real-life study. 27 European Meeting on Hypertension and Cardiovascular Protection. Milan, Italy, 17-19 червня 2017
  11. Dzhus, Y. Boyko. Influence of juvenile idiopathic arthritis on the quality of life of young adults in the transition period to adult rheumatologic care in Ukraine. Щорічний Європейський Конгрес ревматологів”EULAR 2018″, Amsterdam, June 13-16, 2018.
  12. Povoroznyuk, M. Dzhus Bone mineral density, t-score and z-score in young men with juvenile idiopathic arthritis. Щорічний Європейський Конгрес ревматологів”EULAR 2018″, Amsterdam, June 13-16, 2018.
  13. Povoroznyuk, M. Dzhus Age peculiarities of bone mineral density in young female with juvenile idiopathic arthritis. Щорічний Європейський Конгрес ревматологів”EULAR 2018″, Amsterdam, June 13-16, 2018.
  14. Povoroznyuk, M. Dzhus, Peculiarities of bone mineral density in young female with juvenile idiopathic arthritis //WCO-IOF-ESCEO congress (World Congress On Osteoporosis, Osteoarthritis And Musculoskeletal Diseases), Krakow, Poland, April 19-22, 2018. Poster presentation No: p1087
  15. Amosova1, VV. Povoroznyuk, OI. Nishkumay, KP. Lazarieva, GV. Mostbauer, PO. Lazariev, YuV. Rudenko.  Correlation of pulse wave indexes with serum 25(OH) vitamin D level and bone mineral density changes in postmenopausal women with uncomplicated hypertension. 28th ESH Congress 8-11 June 2018. Barcelona
  16. Amosova, O. Vasylenko, J. Rudenko, A. Bezrodniy, G. Mostbauer,
    I. Prydkiy, P. Lazariev, O. Khodakivska, I. Gorda, K. Lazarieva, N. Shiskina, I. Burlachenko. Interrelationship between changes of E/E’ at rest and after exercise and NTproBNP in mild hypertension patients with structural changes and dyspnoea. 28th ESH Congress 8-11 June 2018. Barcelona
  17. Associatiоn of left ventricle diastolic dysfunction, ventricular–vascular coupling and central hemodynamics parameter s in patients with uncomplicated hypertension. Amosova K., Rudenko U., Shyshkina N., Rokyta O., Katsitadze I., Lazareva K., Chernyaeva K. 28th ESH Congress 8-11 June 2018. Barcelona
  18. Amosova, A. Bezrodnyi, G. Mostbauer, A. Sablin, N. Melnychenko. Influence of decongesting therapy on renal function in patients with acute decompensated heart failure, depending on the presence of previous hypertension. Poster presentation on The 27th Scientific Meeting of the International Society of Hypertension, Beijing, China, 20-23 September 2018.

 

Articles by the staff of the department of Internal Medicine  №2 published in journals indexed by Scopus, Web of Science or PubMed.

  1. N.Amosova, U.Rudenko, A.Bezrodniy et al. Can the target doses of medications such as those defined in morbidity – mortality trials ih heart failure patients be realistically achieved in critical routine? Megicographia. 2011, Vol 33 (4) p. 419-420

Controversal question: Can the target doses of medications such as those defined in morbidity-mortality trials in heart failure patients be realistically achieved in clinical routine?

  1. Amosova E. Andrejev & I. Zaderey & U. Rudenko &C. Ceconi & R. Ferrari Efficacy of Ivabradine in Combination with Beta Blocker Versus Uptitration of Beta-Blocker in Patients with Stable Angina// Cardiovascular Drugs and Therapy. December 2011, Volume 25, Issue 6, pp 531–537

https://link.springer.com/article/10.1007%2Fs10557-011-6327-3

  1. Povoroznyuk V.V., Grygorieva N.V., Karasevska T.A., Dzerovich N.I. Bone Mineral Density and Trabecular Bone Score Indices in Women with Rheumatoid Arthritis. According to the Age and Use of Glucocorticoids. SM Rheumatol. 2017; 1(1): 1002. –

smjournals.com/rheumatology/download.php?file=fulltext/smr-v1-1002.pdf

  1. Markku S. Nieminen, Kenneth Dickstein, Cândida Fonseca, Jose Magaña Serrano, John Parissis, Francesco Fedele, Gerhard Wikström, Piergiuseppe Agostoni, Shaul Atar, Loant Baholli, Dulce Brito, Josep Comín Colet, István Édes, Juan E. Gómez Mesa, Vojka Gorjup, Eduardo Herrera Garza, José R. González Juanatey, Nenad Karanovic, Apostolos Karavidas, Igor Katsytadze, Matti Kivikko, Simon Matskeplishvili, Béla Merkely, Fabrizio Morandi, Angel Novoa, Fabrizio Oliva, Petr Ostadal, Antonio Pereira-Barretto, Piero Pollesello, Alain Rudiger, Robert H.G. Schwinger, Manfred Wieser, Igor Yavelov, Robert Zymliński. The patient perspective: Quality of life in advanced heart failure with frequent hospitalisations. International Journal of Cardiology. -2015-Vol.191., P 256-264. DOI: https://doi.org/10.1016/j.ijcard.2015.04.235

https://www.internationaljournalofcardiology.com/article/S0167-5273(15)00969-9/fulltext

  1. Markku S. Nieminen, Michael Buerke, Alain Cohen-Solál, Susana Costa, István Édes, Alexey Erlikh, Fatima Franco, Charles Gibson, Vojka Gorjup, Fabio Guarracino, Finn Gustafsson, Veli-Pekka Harjola, Trygve Husebye, Kristjan Karason, Igor Katsytadze, Sundeep Kaul, Matti Kivikko, Giancarlo Marenzi, Josep Masip, Simon Matskeplishvili, Alexandre Mebazaa, Jacob E. Møller, Jadwiga Nessler, Bohdan Nessler, Argyrios Ntalianis, Fabrizio Oliva, Emel Pichler-Cetin, Pentti Põder, Alejandro Recio-Mayoral, Steffen Rex, Richard Rokyta, Ruth H. Strasser, Endre Zima, Piero Pollesello. The role of levosimendan in acute heart failure complicating acute coronary syndrome: A review and expert consensus opinion. International Journal of Cardiology. -2016. -Vol. 218, p.150–157. DOI: https://doi.org/10.1016/j.ijcard.2016.05.009

https://www.internationaljournalofcardiology.com/article/S0167-5273(16)30911-1/fulltext).

  1. Povoroznyuk V.V., Grygorieva N.V., Karasevska T.A., Dzerovich N.I. Bone Mineral Density and Trabecular Bone Score Indices in Women with Rheumatoid Arthritis. According to the Age and Use of Glucocorticoids. SM Rheumatol. 2017; 1(1): 1002.

 

Abstracts published by the staff of the department of Internal Medicine №2 in foreign editions (2015-2019)

  1. Amosova, A. Bezrodny, I. Gorda, I. Katsytadze, Y. Sychenko, I. Prudkiy, A. Sablin, N. Melnychenko, S. Bogdan, O. Hodakivska. Comparative effects of “nitrate centered” and “diuretic centered” treatment of acute decompensated heart failure on clinical congestion, NT-pro-BNP and tissue doppler parameters. European Heart Journal Acute Cardiovascular Care.– Vol.3.– P.10.
  2. Amosova, A. Bezrodny, I. Gorda, A. Sablin, N. Melnychenko, S. Bogdan, O. Hodakivska, G. Mostbauer,I.Kovaleva, P. Lazarev, I. Prudkiy, I. Katsytadze, Y. Sychenko, O. Vasilenko, K. Chernyaeva. Early acute renal tubular damage during decongestive therapyof acute decompensated heart failure. European Heart Journal. – 2016. – Volume 3. – Abstract Supplement August, p. 239.
  3. Amosova, I. Prudkyi, I. Katsytadze, O. Gerula Evaluating the long-term effectiveness of Levosimendan use on the quality of life in patients with advanced heart failure. Materials of АСС Congress .- 2015. p. 91.
  4. К.М.Амосова, К.П. Лазарева, П.О.Лазарев, Ю.В.Руденко. Effect of calcium channel blocker and different renin-angiotensin-aldosterone system inhibitors on pulse wave analysis indices in mild-moderate uncomplicated hypertensives. Journal of Hypertension Vol 34, e-Supplement 2, September 2016. е 241.
  5. К.М.Амосова, Ю.В.Руденко. Assessment of uncomplicated hypertension therapy effectiveness in real life setting: home blood pressure self-measurement as an alternative to ambulatory 24-hour monitoring Journal of Hypertension Vol 34, e-Supplement 2, September 2016 е 123.
  6. К.М.Амосова, Ю.В.Руденко. Prevalence of true resistant hypertension in uncomplicated hypertensives with apparent treatmentresistant hypertension in longitudinal real-life study Journal of Hypertension Vol 34, e-Supplement 2, September 2016 е172.
  7. К.М.Амосова, Ю.В.Руденко. Effect of algorithmized antihypertensive treatment at masked uncontrolled hypertension persistence in uncomplicated hypertensives European Heart Journal ( 2016 ) 37 ( Abstract Supplement ), Р 66.
  8. I.Nishkumay, I.A Kordubailo., O.A Atamanenko., Z.V. Lysak et. al. Fracrures risk factors analysis in patients with myocardial infarction and coronary atherosclerosis European Journal of Preventive Cardiology (April 2017) 24 (Supplement 1), 126.
  9. Gorda Igor Markers of acute kidney injury in patients with acute decompensated heart failure in the assessment methods decongestion European Heart Journal, Volume 38, Issue suppl_1, 1 August 2017, ehx502. P2467.
  10. M. Amosova, I.U. Rudenko. “Effect of standardized algorithmic treatment on home blood pressure variability: gender differences in longitudinal real-life study.Journal of Hypertension Vol 35, e-Supplement 2, September 2017. e136
  11. Dzhus, Y. Boyko. Influence of juvenile idiopathic arthritis on the quality of life of young adults in the transition period to adult rheumatologic care in Ukraine. //Ann Rheum Dis; V. 77, supplement Suppl, 2018, p. A1660; DOI: 10.1136/annrheumdis-2018-eular.1248
  12. Povoroznyuk, M. Dzhus. Bone mineral density, t-score and z-score in young men with juvenile idiopathic arthritis. // Ann Rheum Dis, volume 77, supplement Suppl, 2018, p. A1765; DOI: 10.1136/annrheumdis-2018-eular.6288.
  13. Povoroznyuk, M. Dzhus. Age peculiarities of bone mineral density in young female with juvenile idiopathic arthritis // Ann Rheum Dis, volume 77, supplement Suppl, 2018, p. A1765; DOI: 10.1136/annrheumdis-2018-eular.6255.
  14. Amosova1, VV. Povoroznyuk, OI. Nishkumay, KP. Lazarieva, GV. Mostbauer, PO. Lazariev, YUV. Rudenko.  Correlation of pulse wave indexes with serum 25(OH) vitamin D level and bone mineral density changes in postmenopausal women with uncomplicated hypertension. Journal of Hypertension Vol 36, e-Supplement 1, June 2018.
  15. Amosova, O. Vasylenko, J. Rudenko, A. Bezrodniy, G. Mostbauer, I. Prydkiy, P. Lazariev, O. Khodakivska, I. Gorda, K. Lazarieva, N. Shiskina, I. Burlachenko. Interrelationship between changes of E/E’at rest and after exercise and NTproBNP in mild hypertension patients with structural changes and dyspnea. Journal of Hypertension Vol 36, e-Supplement 1, June 2018.
  16. Lazarieva K. Amosova O. Nishkumay G. Mostbauer P. Lazariev Y. Rudenko V. Markers of bone remodeling, 25-hydroxycholecalciferol level and lipid metabolism parameters in elderly women with uncompleted arterial hypertension journal of Hypertension: July 2019 – Volume 37 – Issue – p e236 doi: 10.1097/01.hjh.0000573016.15655.0d
  17. EI Levenko , KI Cherniaieva , ZV Lysak , OI Nishkumay , OI Rokyta , NV Shyshkina , AA Kovalenko , AB Yurkovskiy , JM Makuha. How does left ventricle affect left atrium in obese patients with atrial fibrillation and heart failure and preserved ejection fraction? European Journal of Preventive Cardiology, Vol 26, Issue 1_suppl, 2019, S146
  18. Prudkyi I., Antoniuk Yuliia “Hyperuricemia as the miocardial remodeling factor by patients with nonvalvular atrial fibrillation” Proceedings of the first International Conference of European Academy of Science. Oktober 30-31, 2018, Р. 25, Bonn, Germany
  19. Prudkyi I., Mykyta Toliashvili “Ejection fraction as a determining factor of the course of acute myocardial infarction” Proceedings of the first International Conference of European Academy of Science. Oktober 30-31, 2018, Р. 35. Bonn, Germany

 

Textbooks, tutorials and monographs published with the participation of the staff of the department of Internal Medicine №2 (2015-2019)

  1. Внутрішня медицина = Internal medicine : Part 1: textbook for English-speaking students of higher medical schools / edited by Professor M. A. Stanislavchuk and Professor V. K. Sierkova. – Vinnytsya : Nova Knyha, 2019. – 408 p. ISBN 978-966-382-733-9.
  2. Внутрішня медицина = Internal medicine : Part 2 : textbook for English-speaking students of higher medical schools / edited by Professor M. A. Stanislavchuk and Professor V. K. Sierkova. – Vinnytsya : Nova Knyha, 2019. – 360 p. ISBN 978-966-382-733-6.
  3. В.Є. Кондратюк, М.Б. Джус. Внутрішня медицина: ревматологія: навч. посіб. //К. : ВВС “Медицина”, 2017. – 272 с. ISBN 978-617-505-520-5.
  4. Хірургія. Surgery: textbook for student of higher medical educational institutions. K.M. Amosova, Y.S. Berznyts`kyy, A.O.Burka [et al.] Vinnytsia, Nova knyha. 2016. 716p. ISBN 978-966-382-598-4.
  5. Бойко Я.Є., Чернишов В.П., Омельченко Л.І., Грицюк І.І., Романишин Я.Ю., Козак Р.П., Джус М.Б. Ювенільний ідіопатичний артрит.// Львів: Світ, 2017- 176 с. ISBN 978-966-914-060-9

 

 

Grant activity

 

№з/п ПІБ,

посада

Країна Заклад Cпеціальність (тематика) Терміни
1. Кацитадзе І.Ю., асистент кафедри Женева, Швейцарія The International Committee of the Red Cross Health in Detention Project Improvement of the Health services in penitentiary system in Eastern Europe 28.05.2018 – 28. 11.2018
2 Лазарєва К.П., аспірант кафедри Іспанія Hospital Clínico Universitario de Valladolid Кардіологія лютий-липень 2019