<\/p>\n
Responsible person<\/strong> \u2013 Professor of the Department of Neurosurgery,<\/p>\n Medvediev Volodymyr Viktorovych,<\/strong> MD, D.Sc., Professor<\/p>\n contacts:<\/strong> +38 (067) 8591510<\/p>\n +38 (050) 5048788<\/p>\n e-mail: vavo2010@gmail.com<\/p>\n <\/p>\n (Brief Overview)<\/b><\/p>\n <\/p>\n Over nearly half a century, the Department of Neurosurgery at the Bohomolets National Medical University (NMU) has consistently addressed a range of critical biomedical issues. These include the development of restorative neurosurgery methods, studying the pathophysiology and treatment of various nervous system injuries, creating innovative surgical approaches for functional brain pathologies, expanding the experimental neurosurgery research arsenal, exploring neuro-oncology and spinal neurosurgical pathologies, and investigating bioethics, the history of medicine, and neuroscience.<\/span><\/p>\n <\/p>\n Early Period<\/b><\/p>\n <\/p>\n During the early stage, when neurosurgery was a separate course within the Department of Neurology, Associate Professor V.H. Stanislavskyi focused on neuro-oncological issues, particularly meningiomas of the posterior cranial fossa and brain sarcomas, reflected in two fundamental monographs (V.H. Stanislavskyi, 1976; A.P. Romodanov and V.H. Stanislavskyi, 1977). Attention was centered on the relationship between focal and general brain symptoms, tumor development dynamics, and histological types. Clinical studies revealed that focal symptoms depend not only on the location of brain lesions but also on the malignancy, growth rate, and severity of brain responses. Symptoms classically considered indicative of specific brain regions were found to characterize the tumor site only during specific development phases and particular combinations of general and focal reactions.<\/span><\/p>\n <\/p>\n The newly established department, under Professor V.H. Stanislavskyi\u2019s leadership, focused its scientific endeavors on diagnosing and treating craniocerebral trauma, peripheral nerve injuries, spine and spinal cord pathologies, and neuropathic pain syndromes. Clinical and pathophysiological research enhanced understanding of neurodynamic and vascular disorders in the acute phase of closed craniocerebral trauma, which are pivotal in forming clinical pictures and brain edema\/swelling development. During this period, the method of delayed directed pneumoencephalography was optimized for diagnosing craniocerebral trauma sequelae and brain mass lesions. This method involved injecting a small air volume into the lumbar subarachnoid space without cerebrospinal fluid removal, using special projections to enhance ventricle and brain cistern contrast.<\/span><\/p>\n <\/p>\n The department also studied the pathogenesis and treatment of intracranial meningeal hematomas, open craniocerebral trauma, and complications arising from traumatic brain injuries. Under Professor Stanislavskyi\u2019s guidance, the first center for treating peripheral nerve injuries was established. Complementing this, a research project (1981\u20131985) explored new diagnostic methods for peripheral nerve injuries, including liquid cholesterol crystallization, thermovision diagnostics, thermal impulse recording, impedance rheoplethysmography, and a novel microsurgical nerve trauma treatment technique.<\/span><\/p>\n <\/p>\n Research Led by Academician A.P. Romodanov<\/b><\/p>\n <\/p>\n Following the relocation of the department to the Kyiv Institute of Neurosurgery, the scope of scientific research significantly expanded. Under the leadership of Academician A.P. Romodanov from 1986 to 1993, the department focused on neurotrauma, neuro-oncology, functional neurosurgery, pain surgery, and acute cerebral circulation disorders. For example, studies identified the morphological substrate of mild traumatic brain injuries\u2014ultrastructural damage to neurons and glial cells, particularly the pathology of membrane apparatus (O.V. Kopyov, 1988). Professor A.M. Morozov (1988) developed a method for brain tumor chemotherapy in experimental conditions by prolonged drug delivery to the tumor site using polymer-deposited therapeutic forms. Research on the effectiveness of microsurgical brain tumor removal with high-energy lasers, photodynamic therapy for malignant gliomas, and a fundamentally new method\u2014interstitial thermodestruction of deeply located intracerebral tumors\u2014also progressed during this period. However, the most intensive research focus remained on peripheral nerve trauma, as reflected in two research projects conducted between 1986\u20131989 and 1990\u20131993.<\/span><\/p>\n <\/p>\n Functional and Stereotactic Neurosurgery<\/b><\/p>\n <\/p>\n The emergence of this research direction is linked to the addition of Professor V.I. Tsymbaliuk to the department in 1986. While completing his doctoral dissertation under Academician Romodanov\u2019s guidance, Tsymbaliuk developed effective methods and algorithms for neurosurgical treatment of cerebral spasticity. These included stereotactic thalamodentatotomies, thalamopulvinotomies, sagittal cryothalamectomy, radicotomies, neurotomies, myotomies, and more. V.I. Tsymbaliuk\u2019s optimized unilateral stereotactic dentatotomy (cryodestruction of the ventrolateral cerebellar dentate nucleus) reduced spasticity on the side of intervention, while bilateral dentatotomy significantly decreased axial torsion-dystonic hyperkinesias. Beginning in 1986, various clinical studies on functional and stereotactic neurosurgery were conducted at the Kyiv Research Institute of Neurosurgery, with findings published in numerous scientific works. For instance, a comprehensive study on the largest patient sample at the time undergoing functional stereotactic interventions was summarized in the fundamental work \u201cOur Experience of 2220 Stereotactic Operations\u201d by Tsymbaliuk and co-authors in 1990.\u00a0<\/span><\/p>\n <\/p>\n Subsequent dissertations supervised by V.I. Tsymbaliuk addressed functional brain pathology and stereotactic neurosurgery, including those by E.I. Slynyk (1993), K.R. Kostyuk (1999, 2012), M.O. Marushchenko (2005), and Ya.P. Zinkevych (2014). For example, Marushchenko\u2019s dissertation \u201cMorpho-Immunological Correlations in Cryodestruction of Brain Structures\u201d examined morphological and immunological aspects of cryogenic destruction, shedding light on the advantages of alternative neurostimulation procedures.<\/span><\/p>\n <\/p>\n Over the past 15 years, Tsymbaliuk has studied the efficacy of local low-dose botulinum neurotoxin type A for treating blepharospasm, hemifacial spasm, spastic torticollis, oromandibular hyperkinesias, cerebral palsy, and spasticity.<\/span><\/p>\n <\/p>\n Peripheral Nerve Injury Research<\/b><\/p>\n <\/p>\n In 1988, V.I. Tsymbaliuk, with the support of A.P. Romodanov, established a unique clinical division\u2014the Department of Restorative Neurosurgery\u2014at the Institute of Neurosurgery. The primary pathology treated in this department remains peripheral nerve injuries and their consequences. Under V.I. Tsymbaliuk\u2019s leadership, a significant number of dissertations have been completed, focusing on the issue of peripheral nerve trauma. These include works by A.T. Stashkevych (PhD, 1988), O.M. Honda (PhD, 1989), Bunasr Tanios Iosef (PhD, 1990), I.M. Kurylnyi (PhD, 1991), L.O. Lomako (PhD, 1993), I.B. Tretiak (PhD, 1993; DMedSc, 2009), M.S. Kvasha (PhD, 1995), M.M. Suliya (DMedSc, 1997), M.H. Kaddum (PhD, 1997), P.S. Hudak (PhD, 1998), Mohamad Asad (PhD, 1998), O.M. Atanasov (PhD, 1998), S.S. Strafun (DMedSc, 1999), H.M. Fomin (PhD, 1999), Y.V. Pushkar (PhD, 2000), B.M. Luzan (PhD, 2001), Y.V. Baiun (PhD, 2002), D.S. Ivakhnenko (PhD, 2002), K.A. Kardash (PhD, 2003), O.O. Honcharuk (DMedSc, 2005; PhD, 2021), H.I. Dubyna (PhD, 2005), M.A. Sapon (DMedSc, 2007), M.A. Yenikiev (PhD, 2007), A.M. Kardash (DMedSc, 2009), O.Ye. Kucheriuk (PhD, 2014), O.O. Hatskyi (PhD, 2015), M.M. Tatarchuk (PhD, 2015), T.I. Petriv (PhD, 2019), V.Yu. Molotkovets (PhD, 2020), Hao Jiang (PhD, 2020), and a dissertation by the department\u2019s postgraduate student Ya.V. Tsymbaliuk (PhD, 2020), supervised by I.B. Tretiak and V.V. Medvediev.<\/span><\/p>\n <\/p>\n Among the studies on peripheral nerve trauma, notable works include research on the effects of low doses of ionizing radiation on the progression of this type of injury (monograph edited by Y.P. Zozulia, 1998), early studies on gunshot injuries to peripheral nerves (Y.V. Pushkar, PhD, 2000), and brachial plexus injuries (monograph by V.I. Tsymbaliuk and co-authors, 2001; awarded the Ukrainian Academy of Medical Sciences Prize, 2003).<\/span><\/p>\n <\/p>\n Several works under V.I. Tsymbaliuk\u2019s guidance have focused on chronic pain (I.P. Dmyterko, PhD, 2003), a common cause of which is peripheral nerve trauma (M.A. Sapon, DMedSc, 2007).<\/span><\/p>\n <\/p>\n Another related topic\u2014surgical treatment of peripheral nerve tumors\u2014has been the subject of three candidate dissertations (Bunasr Tanios Iosef, 1990; M.D. Tonchev, 2011; V.M. Konakh, 2015) and one doctoral dissertation (M.V. Kvasnytskyi, 2004), as well as a scientific monograph (V.I. Tsymbaliuk, M.V. Kvasnytskyi, 2005). Additionally, techniques for electrophysiological diagnosis of peripheral nerve pathology were detailed in a monograph by V.I. Tsymbaliuk and co-authors in 2005.<\/span><\/p>\n <\/p>\n It is also worth noting that in 1996, a series of works by a team of authors, including V.I. Tsymbaliuk, dedicated to the treatment of peripheral nerve injuries, was awarded the State Prize of Ukraine in Science and Technology.<\/span><\/p>\n <\/p>\n A creative team consisting of V.I. Tsymbaliuk, I.B. Tretiak, M.A. Sapon, and S.Ye. Shoferistov developed and implemented the \u201cNeiSi-3M\u201d electrical stimulator into the practice of restorative treatment for peripheral nerve injuries. Subsequently, the regenerative effect of modulated alternating electric current on damaged nerve trunks was demonstrated (Tsymbaliuk Yu.V., DMedSc, 2014).<\/span><\/p>\n <\/p>\n Over the 35 years of the Restorative Neurosurgery Clinic\u2019s existence under the leadership of V.I. Tsymbaliuk, an equal number of dissertations have been completed, thoroughly exploring the clinical, morphological, functional, and age-related features of peripheral nerve injuries and proposing new methods for the surgical and rehabilitative treatment of this pathology.<\/span><\/p>\n <\/p>\n Neurotransplantology and Restorative Neurosurgery<\/b><\/p>\n <\/p>\n Since the late 1980s, under the leadership of A.P. Romodanov and later V.I. Tsymbaliuk, the department has been investigating the surgical restoration of nervous system structures, particularly through tissue and cellular neurotransplantation and, more recently, artificially engineered bioengineered transplants.<\/span><\/p>\n <\/p>\n The study of tissue neurotransplantation spanned 20 years, during which over a dozen research projects were conducted, involving neuroimmunologists, biochemists, molecular biologists, morphologists, cell culture specialists, and experimental neurosurgeons from the Ukrainian Institute of Neurosurgery. The results of this research were presented in about 20 dissertations supervised by V.I. Tsymbaliuk, including those by L.D. Pichkur (PhD, 1993; DMedSc, 2009), E.I. Slynko (PhD, 1993), S.O. Yavorska (PhD, 1997), I.M. Shcherba (PhD, 1999), N.O. Pichkur (PhD, 1999), K.R. Kostyuk (PhD, 1999), L.V. Bodnar (PhD, 2000), V.L. Didkovsky (PhD, 2000), B.M. Luzan (PhD, 2001), O.I. Troyan (PhD, 2002), M.R. Radchenko (PhD, 2003), Yu.Ya. Yaminsky (PhD, 2003), V.A. Vasyuta (PhD, 2005), D.Yu. Latyshev (PhD, 2006), Yu.A. Kasyanenko (PhD, 2006), Yu.Yu. Senchyk (PhD, 2011), E.S. Yarmolyuk (PhD, 2016), and V.V. Medvediev (DMedSc, 2017). The effectiveness of tissue neurotransplantation was studied for various conditions: traumatic brain injuries (L.D. Pichkur, I.M. Shcherba, O.I. Troyan, Yu.Yu. Senchyk), peripheral nerve injuries (B.M. Luzan), spinal cord trauma (Yu.Ya. Yaminsky, V.V. Medvediev), cerebral ischemia (L.V. Bodnar, E.S. Yarmolyuk), cerebral palsy (N.O. Pichkur, S.O. Yavorska), apallic syndrome (D.Yu. Latyshev), network disorders of brain function (E.I. Slynko), auditory analyzer pathology (V.L. Didkovsky), and visual analyzer pathology (M.R. Radchenko). With few exceptions, these studies were experimental.<\/span><\/p>\n <\/p>\n Subsequently, under V.I. Tsymbaliuk\u2019s guidance, the effectiveness of cellular neurotransplantation was tested (V.V. Medvediev, PhD, 2008; V.V. Kolesnyk, PhD, 2014), as well as the transplantation of bioengineered composites (V.V. Medvediev, PhD, 2008; O.O. Hatskyi, PhD, 2015; V.V. Medvediev, DMedSc, 2017; T.I. Petriv, PhD, 2019) for various nervous system pathologies. These studies are ongoing under the leadership of V.V. Medvediev, involving researchers such as I.M. Abdalla (PhD, 2022) and postgraduate students Z.K. Melikov and V.M. Sagaidak.<\/span><\/p>\n <\/p>\n ___<\/span><\/p>\n A section of PNRMA hydrogel material combined with xenogenic neural (A) or mesenchymal (B) stem cells, implanted into the site of a hemisection of the rat spinal cord, at the 7th month of observation.<\/span> Green color<\/span> represents the green fluorescent protein (GFP) used to mark the transplanted cells; <\/span>red color<\/span> indicates a marker for neurons and their axons, BIII-tubulin; <\/span>blue<\/span> color<\/span> shows the marker for astrocytic glia, glial fibrillary acidic protein (GFAP); \u201cmerged\u201d is the confocal overlay of both marker expression images. Arrows point to the progeny of transplanted cells, some of which have likely differentiated into neuronal or glial pathways. Nerve fibers (red fibers and threads) grow into the hydrogel implant material between the grooves of the hydrogel substance (black uncolored grooved zones). The material was obtained and processed by V.V. Medvediev and O.A. Rybychuk.<\/span><\/p>\n ___<\/span><\/p>\n <\/p>\n ___<\/span><\/p>\n Approval of a New Matrix for Spinal Cord Injury Restoration. The matrix was made from polyethylene glycol using two-photon polymerization stereolithography technology. The width of the microtunnels is 50 \u00b5m, the width of the implant is 1 mm, the length is 1 mm, and the shape is cylindrical. After excising a 1-mm fragment of the left half of the spinal cord from a 1-month-old rat (A), the implant was inserted into the defect area (B), and after 3 months, it was observed in a longitudinal section of the spinal cord (C). The tunnels were filled with regrown spinal cord tissue, resembling longitudinal strands of <\/span>turquoise color<\/span> (D, E), and the area of their entry into the tunnels is shown in microphotograph E. The matrix substance and glial fibrillary acidic protein (GFAP) are <\/span>green<\/span>, and the myelin basic protein (MBP) is turquoise. <\/span>The idea was conceived by P. Bilan, the implant was made by S. Grebinyuk, injury modeling and implantation were performed by V. Medvediev, and immunohistochemical research was conducted by O. Rybychuk, P. Bilan, and Y. Sheremet.<\/b><\/p>\n ___<\/span><\/p>\n <\/p>\n In total, six monographs have been dedicated to the topic of neurotransplantology: authored by V.I. Tsymbaliuk and V.V. Medvediev (2005, 2010, 2023), Yu.P. Zozulia and co-authors (2005), V.I. Tsymbaliuk and co-authors (2005), and V. Tsymbaliuk, V. Medvediev, and Yu. Senchyk (2013).<\/span><\/p>\n <\/p>\n For their research in regenerative medicine, V.I. Tsymbaliuk, along with a group of Ukrainian scientists, was awarded the State Prize of Ukraine in Science and Technology (2002), and V.V. Medvediev and co-authors received the Boris Paton National Prize of Ukraine (2021).<\/span><\/p>\n <\/p>\n Among the wide range of conditions studied for the effectiveness of neurotransplantation treatments, spinal cord injuries stand out. New treatment methods for this pathology have been explored in numerous dissertations supervised by V.I. Tsymbaliuk (A.T. Stashkevych, DMedSc, 1997; Yu.Ya. Yaminsky, PhD, 2003; DMedSc, 2012; V.V. Medvediev, PhD, 2008; DMedSc, 2017; Ye.V. Cheshuk, PhD, 2024) and V.V. Medvediev (I.M. Abdalla, PhD, 2022). For instance, V.I. Tsymbaliuk, together with Yu.Ya. Yaminsky, I.B. Tretiak, M.A. Sapon, and Ye.V. Cheshuk, demonstrated that prolonged electrical spinal cord stimulation under specific modes improves motor function recovery, pelvic organ innervation, and reduces spasticity and pain symptoms. Both literary data and their own experimental studies on restorative treatments for spinal cord trauma are detailed in four monographs (V.I. Tsymbaliuk, V.V. Medvediev, 2005, 2010; V.I. Tsymbaliuk, Yu.Ya. Yaminsky, 2009; V. Tsymbaliuk, V. Medvediev, 2023).<\/span><\/p>\n <\/p>\n Combat Trauma and Military Medicine<\/b><\/p>\n <\/p>\n The issue of combat trauma to the nervous system was addressed in the department\u2019s research long before the beginning of Russian aggression. For instance, Y.V. Pushkar\u2019s work (PhD, 2000) studied gunshot injuries to the nerves of the upper and lower limbs during peacetime, while a monograph by V.I. Tsymbaliuk and V.V. Mohyla (2008) focused on gunshot trauma to the central nervous system.<\/span><\/p>\n <\/p>\n Since the onset of Russian aggression, V.I. Tsymbaliuk organized efforts within the National Academy of Medical Sciences of Ukraine (NAMSU) to generalize acquired military-medical experience, study the specifics of modern combat trauma, optimize treatment protocols, and further rehabilitate the wounded. Under his leadership, two research projects (2016\u20132021) were carried out, analyzing the experience of neurosurgical treatment of combat peripheral nerve trauma based on clinical material from the Restorative Neurosurgery Clinic of the A.P. Romodanov Institute of Neurosurgery, NAMSU. Under V.I. Tsymbaliuk\u2019s guidance, experimental ballistic studies are being conducted within interdepartmental scientific collaboration.<\/span><\/p>\n <\/p>\n From an organizational standpoint, under V.I. Tsymbaliuk\u2019s leadership, NAMSU initiated and developed the national military-medical doctrine, which was approved by a resolution of the Cabinet of Ministers of Ukraine. This doctrine defines the rules and principles for the operation of all military and civilian medical institutions in Ukraine during wartime, states of emergency, and peacetime.<\/span><\/p>\n <\/p>\n To date, the accumulated experience in organizing and providing medical care in the context of military operations has been outlined in 15 monographs and manuals, edited or co-authored by V.I. Tsymbaliuk. Work on systematizing and summarizing the acquired data continues.<\/span><\/p>\n <\/p>\n Other Research Areas<\/b><\/p>\n <\/p>\n Since the founding of the department, research into neuro-oncology has been ongoing. Over time, this topic has been addressed in the dissertations of Bunasr Tanios Iosef (PhD, 1990), Sakar Basam M. (PhD, 1991), A.I. Yermoliev (PhD, 1999), M.V. Kvasnytskyi (DMedSc, 2004), Ya.I. Sydor (PhD, 2009), M.D. Tonchev (PhD, 2011), Ya.P. Zinkevych (PhD, 2014), and V.M. Konakh (PhD, 2015). The establishment, thanks to the organizational efforts of V.I. Tsymbaliuk, of a national radiosurgery center at the A.P. Romodanov Institute of Neurosurgery, NAMSU, undoubtedly has significant practical and scientific implications.<\/span><\/p>\n <\/p>\n The department has also focused on craniocerebral trauma and its consequences, which has been the subject of dissertations by L.D. Pichkur (PhD, 1993), I.M. Shcherba (PhD, 1999), V.M. Zhdanova (PhD, 2000), O.I. Troyan (PhD, 2002), H.I. Dubyna (PhD, 2005), D.Yu. Latyshev (PhD, 2006), D.V. Yevminov (PhD, 2009), A.P. Englezi (DMedSc, 2010), Yu.Yu. Senchyk (PhD, 2013), and P.P. Makovetskyi (PhD, 2019).<\/span><\/p>\n ___<\/span><\/p>\n Collection and cryopreservation of brain glioma tissue during its surgical removal for further molecular studies. The surgeon is Assistant Professor V.Yu. Molotkovets, operating room at the A.P. Romodanov Institute of Neurosurgery, NAMSU.<\/span><\/p>\n ___<\/span><\/p>\n <\/p>\n ___<\/span><\/p>\n Work in the operating room of the experimental animals clinic (vivarium) at the A.P. Romodanov Institute of Neurosurgery, NAMSU. PhD students of the department <\/span>Z.K. Melikov<\/b> (modeling of sciatic nerve injury in rats) and <\/span>V.M. Sagaydak<\/b> (modeling of spinal cord injury in rats).<\/span><\/p>\n ___<\/span><\/p>\n <\/p>\n The issues of acute cerebrovascular disorders and their consequences were addressed in the research of V.M. Zhdanova (PhD, 2000), L.V. Bodnar (PhD, 2000), V.V. Kolesnyk (PhD, 2014), A.I. Zozulia (DMedSc, 2014), and E.S. Yarmolyuk (PhD, 2016). The importance of qualitative neuroimaging in diagnosing neurological and neurosurgical pathologies was studied in the work of O.S. Pryvalova (PhD, 1999) and in the monograph by A.M. Morozov and co-authors (2007).<\/span><\/p>\n <\/p>\n A separate monograph, approximately 20 other printed works, and three dissertations supervised by V.I. Tsymbaliuk (I.P. Tkachyk, PhD, 2002; Ya.P. Zinkevych, PhD, 2014; Yu.A. Yasharov, PhD, 2017; P.P. Makovetskyi, PhD, 2019) are dedicated to the issue of purulent-inflammatory complications of neurosurgical and related pathologies.<\/span><\/p>\n <\/p>\n Under the adjacent leadership of V.I. Tsymbaliuk, the department also conducted research in collaboration with specialists from other fields, including otorhinolaryngology (Fennish Nureddin, PhD, 1991; Didkovsky V.L., PhD, 2000), ophthalmology (Zhdanova V.M., PhD, 2000; Radchenko M.R., PhD, 2003; Vasyuta V.A., PhD, 2006; Konakh V.M., PhD, 2015), and physical rehabilitation (M. Asad, PhD, 1998; A.T. Stashkevych, DMedSc, 1997; O.B. Sopukha, PhD, 2000; M.S. Brovchenko, PhD, 2006; O.B. Lazareva, DMedSc, 2013).<\/span><\/p>\n <\/p>\n The longstanding body of work by Professor A.M. Morozov, dedicated to the issue of quality in the healthcare system, should also be noted. This includes monographs by A.M. Morozov and co-authors (2002), D.V. Varyvonchik and co-authors (2006), and V.T. Chumak and co-authors (2008), as well as works on standardizing neurosurgical care (Protocols\u2026, 2006; Standardization\u2026, 2019, 2020) and the rational use of pharmaceuticals (Formulary of Medicinal Products\u20142009, 2013, 2014, 2016).<\/span><\/p>\n <\/p>\n Historical Research<\/b><\/p>\n <\/p>\n Under the leadership of V.I. Tsymbaliuk, the department has been conducting research on the history of domestic neuroscience, medical science, and neurosurgical practice for 20 years. This topic has been addressed in around 30 monographic studies and several works in professional periodicals. In addition to the comprehensive exploration of the life and achievements of his mentor, Academician A.P. Romodanov (monographs from 1996, 2002, 2010, and 2020), V.I. Tsymbaliuk has published biographies of the academic figures O.I. Arutyunov (2004), Yu.P. Zozulia (2007, 2008, 2012), Yu.I. Kundiev (2017), V.I. Hryshchenko (2012), V.F. Moskalenko (2009), corresponding member of NAMSU M.Ye. Poliashchuk (2004), professors L.P. Chepkov (2006) and B.S. Khominskyi (2011).<\/span><\/p>\n <\/p>\n In 2014, V.I. Tsymbaliuk published the monograph \u201cHistory of Ukrainian Neurosurgery in Portraits,\u201d which presents historical research on twelve of the most prominent figures in Ukrainian neuroscience and neurosurgery, including V.O. Betz, P.S. Babitsky, L.O. Koreysha, P.S. Tarasenko, O.I. Arutyunov, A.P. Romodanov, M.K. Brotman, T.M. Serhiienko, B.S. Khominskyi, O.L. Dukhin, L.Ye. Pelekh, and O.O. Laponohov. Under V.I. Tsymbaliuk\u2019s editorial guidance, two bibliographic guides \u201cNeurosurgeons of Ukraine\u201d were published (1993, 2008). Additionally, V.I. Tsymbaliuk\u2019s creative work includes monographs dedicated to the history of the Institute of Neurosurgery, NAMSU (2006, 2010), NMU (2012), and specifically the Department of Neurosurgery (2010), as well as the history and present of NAMSU (1998, 2007, 2013, 2018, 2019). V.I. Tsymbaliuk has also created five documentaries about the history of the Institute of Neurosurgery, NAMSU, its first directors O.I. Arutyunov and A.P. Romodanov, as well as the history and present of the NMU Department of Neurosurgery.<\/span><\/p>\n <\/p>\n In recent years, staff from the Departments of Neurosurgery and Descriptive and Clinical Anatomy at NMU have been actively researching the work of V.O. Betz (V.V. Medvediev, V.H. Cherkasov, V.I. Tsymbaliuk, M.O. Marushchenko) and V.F. Voyno-Yasenetsky (V.V. Medvediev), which has been reflected in a series of published works.<\/span><\/p>\n <\/p>\n The Role in formation of the Ukrainian Neurosurgical School<\/b><\/p>\n <\/p>\n It is now evident that the heads of the Department of Neurosurgery at NMU, Academicians A.P. Romodanov and V.I. Tsymbaliuk, made fundamental contributions to the formation of domestic medical schools.\u00a0<\/span><\/p>\n A.P. Romodanov was a long-time organizer of medical science in Ukraine, the builder of the A.P. Romodanov Institute of Neurosurgery, one of the founders of the National Academy of Medical Sciences of Ukraine (NAMSU), and the founder of the domestic neurosurgical school.<\/span><\/p>\n V.I. Tsymbaliuk held the position of Deputy Director for Scientific Work at the A.P. Romodanov Institute of Neurosurgery (1993\u20132013), Vice President of the Ukrainian Association of Neurosurgeons, and Deputy Chair and Chair of the Specialized Scientific Council for Dissertation Defense at the Institute of Neurosurgery. In addition, V.I. Tsymbaliuk has led the Coordination Center for Organ, Tissue, and Cell Transplantation at the Ministry of Health of Ukraine (2002\u20132004), the Scientific Council on Clinical Medicine at NAMSU (2013\u20132016), and has served as Vice President and, since 2016, President of NAMSU. During his tenure as head of the department, V.I. Tsymbaliuk formed a compact and harmonious team, ensuring the necessary scientific productivity even in the present challenging conditions.<\/span><\/p>\n Under the leadership of A.P. Romodanov and V.I. Tsymbaliuk, a wide range of educational and methodological materials has been created, and numerous manuals, textbooks, and guidelines have been published, forming the essential foundation for training scientific personnel. Over the course of the department\u2019s existence, approximately 50,000 students, 30 clinical residents, 4 master\u2019s degree students, and more than 35 PhD candidates have been trained.<\/span><\/p>\n <\/p>\n ***<\/span><\/p>\n <\/p>\n In summary, it should be noted that the Department of Neurosurgery at NMU has played and continues to play a significant role in the development of domestic medical science. Currently, the scientific focus of the department covers the issues of restorative and experimental neurosurgery, addressing unresolved problems in peripheral nerve injuries, spinal cord trauma, degenerative disc diseases, neuro-oncology, as well as bioethics and the history of medicine. Perhaps the most powerful scientific and practical direction of the department over the past thirty years has been the development of restorative neurosurgery and neurotransplantology.<\/span><\/p>","protected":false},"excerpt":{"rendered":" Responsible person \u2013 Professor of the Department of Neurosurgery, Medvediev Volodymyr Viktorovych, MD, D.Sc., Professor contacts: +38 (067) 8591510 +38 (050) 5048788 e-mail: vavo2010@gmail.com (Brief Overview) Over nearly half a century, the Department of Neurosurgery at the Bohomolets National Medical University (NMU) has consistently addressed a range of critical biomedical issues. 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