{"id":11211,"date":"2016-06-11T19:30:42","date_gmt":"2016-06-11T19:30:42","guid":{"rendered":"http:\/\/nmu.ua\/kafedri\/kafedra-fyzyologyy\/naukova-robota\/"},"modified":"2026-05-28T09:36:33","modified_gmt":"2026-05-28T06:36:33","slug":"naukova-robota","status":"publish","type":"page","link":"https:\/\/nmuofficial.com\/en\/zagalni-vidomosti\/kafedri\/kafedra-fyzyologyy\/naukova-robota\/","title":{"rendered":"SCIENTIFIC WORK"},"content":{"rendered":"<p><strong>Responsible person <\/strong><\/p>\n<p><strong>Tarasova Kateryna, PhD, Associate professor, <\/strong><strong>flokalin1@gmail.com<\/strong><strong>.<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Research Activities<\/strong><\/p>\n<p><strong>Departmental Repository<\/strong><\/p>\n<p>Department of Physiology Repository:<br \/>\n<a href=\"http:\/\/ir.librarynmu.com\/handle\/123456789\/123\">http:\/\/ir.librarynmu.com\/handle\/123456789\/123<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Research Project of the Department of Physiology (2024\u20132026)<\/strong><\/p>\n<p><strong>\u201cFeatures of Ovarian Function under Experimental Hyperglycemia and the Use of Gold Nanoparticles\u201d<\/strong><\/p>\n<p><strong>Project Leader:<\/strong><br \/>\nHead of Department, PhD in Medicine, Associate Professor\u00a0<strong>Ihor Karvatskyi<\/strong><\/p>\n<p><strong>Responsible Researchers:<\/strong><\/p>\n<ul>\n<li>PhD in Medicine, Associate Professor\u00a0<strong>Kateryna Tarasova<\/strong>(<a href=\"mailto:flokalin1@gmail.com\">flokalin1@gmail.com<\/a>)<\/li>\n<li>PhD in Medicine, Assistant Lecturer\u00a0<strong>Nataliia Motorna<\/strong>(<a href=\"mailto:natalivfrcbv@gmail.com\">natalivfrcbv@gmail.com<\/a>)<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Aim of the Study<\/strong><\/p>\n<p>To evaluate the effect of different concentrations of gold nanoparticles (GNPs) on the reproductive function of female mice under conditions of experimental hyperglycemia.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Research Objectives<\/strong><\/p>\n<ol>\n<li>To investigate the reproductive function of female mice under experimental hyperglycemia, specifically determining the proportions of viable and apoptotic, necrotic, and autophagic cells in the follicular environment of oocytes.<\/li>\n<li>To study the effects of antioxidants (vitamins A and C) on ovarian cell function.<\/li>\n<li>To assess the influence of gold nanoparticles D\u2011g\u2011PAA(PE)\/AuNP (0.10 \u03bcM, 1.0 \u03bcM, 10.0 \u03bcM) and AuNPs (ALDRICH) (1.0 \u03bcM and 10.0 \u03bcM) on reproductive function, including the proportions of viable and apoptotic, necrotic, and autophagic follicular cells.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><strong>Scientific Novelty<\/strong><\/p>\n<ol>\n<li>For the first time, the effects of gold nanoparticles on the reproductive function of female mice under experimental hyperglycemia will be investigated.<\/li>\n<li>A comparative analysis of the effectiveness of different concentrations of gold nanoparticles on reproductive outcomes will be conducted.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><strong>Practical Significance<\/strong><\/p>\n<p>The planned research\u2014evaluating the impact of GNP administration on oocytes, follicular cells, and pre\u2011 and post\u2011implantation embryonic mortality in mice\u2014may facilitate the translation of gold nanotechnology into clinical practice.<br \/>\nThe results are expected to contribute to the development of\u00a0<strong>safe, cost\u2011effective, and environmentally friendly GNP\u2011based therapeutic agents<\/strong>, as well as to a deeper understanding of their mechanisms of action under experimental conditions.<\/p>\n<p>The findings will be used:<\/p>\n<ul>\n<li>in the educational process at the Department of Physiology,<\/li>\n<li>in preclinical studies at the O.O. Bohomolets Institute of Physiology,<\/li>\n<li>in healthcare practice within specialized medical institutions.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Research Timeline<\/strong><\/p>\n<ul>\n<li><strong>December 2023<\/strong>\u2014 Project planning<\/li>\n<li><strong>2024<\/strong>\u2014 Study of ovarian cell function under experimental hyperglycemia<\/li>\n<li><strong>2025<\/strong>\u2014 Study of the effects of antioxidants (vitamins A and C) on ovarian cell function<\/li>\n<li><strong>2026<\/strong>\u2014 Study of the effects of different concentrations of gold nanoparticles on ovarian cells (oocytes)\u00a0<em>in vitro<\/em><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<div class=\"empty\">\n<ul>\n<li><strong>Main directions of work<\/strong>in 2017-2020 arethe following: the methods of cardiovascular system`s studying, theregulationofmembraneandmitochonrialchannels of cardiomyocytes, age peculiarities of functioning of cardiomyocytes and the cells of smooth muscles of vessels.<\/li>\n<li><strong>Researchwork<\/strong><\/li>\n<\/ul>\n<p>Scientificresearchwork, whichhasbeenscheduledfor 2017-2020:\u201cThe research of membrane and intracellular regulatory mechanisms of cardiomyocytes and smoothmuscular cells` activity under different functional states\u201d.<\/p>\n<ul>\n<li>Thescientificresearchwork, whichwasfulfilledin 2019:\u00abThestudyofmembranemechanismsof arterial pressure regulation and electric processes in myocardium\u00bb<\/li>\n<\/ul>\n<p>Monograph:<\/p>\n<ol>\n<li>LiudmylaKlymenko, History of formation and development of Kyiv physiological schools (end of XIX century &#8211; XX centuries). &#8211; K.: Phytocenter, 2017. &#8211; 271 p.<\/li>\n<li>Publishingactivities in 2019.<\/li>\n<li>\u0424\u0456\u0437\u0456\u043e\u043b\u043e\u0433\u0456\u044f. \u0417\u0430 \u0440\u0435\u0434\u0430\u043a\u0446\u0456\u0454\u044e \u0406.\u041c.\u041a\u0430\u0440\u0432\u0430\u0446\u044c\u043a\u043e\u0433\u043e. \u041d\u0430\u0432\u0447\u0430\u043b\u044c\u043d\u0438\u0439 \u043f\u043e\u0441\u0456\u0431\u043d\u0438\u043a \u0434\u043e \u043f\u0440\u0430\u043a\u0442\u0438\u0447\u043d\u0438\u0445 \u0437\u0430\u043d\u044f\u0442\u044c \u0456 \u0441\u0430\u043c\u043e\u0441\u0442\u0456\u0439\u043d\u043e\u0457 \u0440\u043e\u0431\u043e\u0442\u0438 \u0441\u0442\u0443\u0434\u0435\u043d\u0442\u0456\u0432. \u0423 2-\u0445 \u0442\u043e\u043c\u0430\u0445. \u2012 \u041a.: \u0424\u0435\u043d\u0456\u043a\u0441, 2019. \u0422.1 \u2013 352 \u0441.<\/li>\n<li>\u041f\u0440\u0430\u043a\u0442\u0438\u043a\u0443\u043c \u043f\u043e \u0444\u0438\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u0438. \u041f\u043e\u0434\u0440\u0435\u0434\u0430\u043a\u0446\u0438\u0435\u0439\u0418.\u041d.\u041a\u0430\u0440\u0432\u0430\u0446\u043a\u043e\u0433\u043e. \u041f\u043e\u0441\u043e\u0431\u0438\u0435 \u043a \u043f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0437\u0430\u043d\u044f\u0442\u0438\u044f\u043c \u0438 \u0441\u0430\u043c\u043e\u0441\u0442\u043e\u044f\u0442\u0435\u043b\u044c\u043d\u043e\u0439\u0440\u0430\u0431\u043e\u0442\u0435\u0438\u043d\u043e\u0441\u0442\u0440\u0430\u043d\u043d\u044b\u0445\u0441\u0442\u0443\u0434\u0435\u043d\u0442\u043e\u0432 \u0441 \u0440\u0443\u0441\u0441\u043a\u0438\u043c\u044f\u0437\u044b\u043a\u043e\u043c\u043e\u0431\u0443\u0447\u0435\u043d\u0438\u044f. \u0412 2-\u0445 \u0442\u043e\u043c\u0430\u0445. \u2012 \u041a.: \u0424\u0435\u043d\u0438\u043a\u0441, 2019. \u0422.1 \u2013 278 \u0441.<\/li>\n<li>Practicalworksinphysiology. EditedbyI.M.Karvatsky. TextbookforpracticalstudiesandindividualworkforEnglish-speakingstudents. 2-th Vol. \u2013 Kyiv. Phoenix, 2019. V.1 \u2013 296 p.<\/li>\n<\/ol>\n<p>In 2019, 4 articleswerepublishedinScopusindexedJournals, 5 articlesinprofessional Journals of SAC of the Ministry of Science and education, 2 articles in other publications.<\/p>\n<\/div>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Responsible person Tarasova Kateryna, PhD, Associate professor, flokalin1@gmail.com. &nbsp; Research Activities Departmental Repository Department of Physiology Repository: http:\/\/ir.librarynmu.com\/handle\/123456789\/123 &nbsp; Research Project of the Department of Physiology (2024\u20132026) \u201cFeatures of Ovarian Function under Experimental Hyperglycemia and the Use of Gold Nanoparticles\u201d Project Leader: Head of Department, PhD in Medicine, Associate Professor\u00a0Ihor Karvatskyi Responsible Researchers: PhD in [&hellip;]<\/p>\n","protected":false},"author":69,"featured_media":0,"parent":11205,"menu_order":60,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"footnotes":""},"class_list":["post-11211","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/nmuofficial.com\/en\/wp-json\/wp\/v2\/pages\/11211","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nmuofficial.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nmuofficial.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nmuofficial.com\/en\/wp-json\/wp\/v2\/users\/69"}],"replies":[{"embeddable":true,"href":"https:\/\/nmuofficial.com\/en\/wp-json\/wp\/v2\/comments?post=11211"}],"version-history":[{"count":3,"href":"https:\/\/nmuofficial.com\/en\/wp-json\/wp\/v2\/pages\/11211\/revisions"}],"predecessor-version":[{"id":225362,"href":"https:\/\/nmuofficial.com\/en\/wp-json\/wp\/v2\/pages\/11211\/revisions\/225362"}],"up":[{"embeddable":true,"href":"https:\/\/nmuofficial.com\/en\/wp-json\/wp\/v2\/pages\/11205"}],"wp:attachment":[{"href":"https:\/\/nmuofficial.com\/en\/wp-json\/wp\/v2\/media?parent=11211"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}